Results 61 to 70 of about 11,345,916 (326)

The Metacity: A Conceptual Framework for Integrating Ecology and Urban Design

Challenges, 2011
We introduce the term metacity as a conceptual framework that can be shared by ecologists and designers and applied across the wide variety of urban habitats found around the world.
S. T. A. Pickett, Brian McGrath
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Study on the influencing factors of photovoltaic siting in coal mining subsidence areas–taking Shanxi Province as an example

Scientific Reports
Developing photovoltaic (PV) projects in coal mining subsidence areas represents a strategic pathway to improving land use efficiency and accelerating the transition to renewable energy.
Yan Lu, Yu Yan, Mengyao Wang, Long Zhou
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Applying Delphi method to develop sustainable city indexes

TeMA: Journal of Land Use, Mobility and Environment, 2023
Cities around the world have expanded and consumed many resources. The expansion of these cities has had a huge impact on our planet. There are many ideas about sustainable urban development around the world to slow down or stop the destruction of the ...
Wiwat Pongruengkiat, Korrakot Y. Tippayawong, Pruk Aggarangsi, Preda Pichayapan, Tossapon Katongtung, Nakorn Tippayawong   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Contemporary Concepts of a City in the Context of Sustainable Development: Perspective of Humanities and Natural Sciences

Problemy Ekorozwoju, 2016
The article’s purpose is to present, in the first place, mutual dependences between theoretical and practical speculations concerning urban space, shaped on the base of the sustainable development principle, difficult to implement in practice. Secondly,
Marcin Leźnicki, Aleksandra Lewandowska
doaj  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Sustainable City Planning Concepts and Practices in Emerging Economies: A Systematic Review

, 2020
The purpose of this paper is to explore sustainable city planning concepts and practices in emerging economies. Using a systematic review, peer-reviewed articles in an academic database were systematically searched and reviewed.
C. Permana, B. Harsanto
semanticscholar   +1 more source