Results 161 to 170 of about 202,661 (304)
A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates
Advanced Science, EarlyView.Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao +7 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen +7 more
wiley +1 more source
The Egyptian International Journal of Engineering Sciences and Technology, 2021 openaire +2 more sources
City-zen 'Preston' Roadshow - Site Specific EVENT [PDF]
The City-zen Roadshow's are 'site specific performance based' interactive events that bring together experts and city stakeholders 'onsite' to co-creatively design a future sustainable vision for their city.
Keeffe, Greg +7 more
core
Advanced Science, EarlyView.A layered bead‐network wallpaper is designed to modulate the light propagation path, overcoming the color residue limitations of thermochromic components for efficient automatic switching between radiative cooling and solar heating modes. The layered bead‐network wallpaper provides passive, all‐season thermal regulation while offering self‐cleaning and
Jianyu Wu +7 more
wiley +1 more source
Advanced Science, EarlyView.Monolithically integrated Sb2S3 on industry‐compatible textured silicon for tandem photoelectrochemical hydrogen evolution coupled with iodide oxidation. ABSTRACT Solar‐driven photoelectrochemical (PEC) production of chemical fuels such as hydrogen is a viable solution to address climate neutrality objectives.
Jihong Min +13 more
wiley +1 more source
Hierarchical Twin Networks Enable Exceptional Strength and Fracture Toughness in Titanium
Advanced Science, EarlyView.A commercial‐purity titanium with hierarchical ultrafine twin structures delivers an exceptional combination of fracture toughness (KJIc) of 187 MPa·m1/2 and specific yield strength of 140 MPa·cm3·g−1, in which pre‐engineered high‐density twin boundaries stimulate massive and
Xiao‐Wei Zou +3 more
wiley +1 more source
Sub‐Terahertz Memristor Switches Using MoS2 by Liquid–Liquid Interface Assembly
Advanced Science, EarlyView.This work introduces application‐ready sub‐terahertz memristor switches fabricated from electrochemically exfoliated MoS2 nanosheets assembled at a liquid–liquid interface. The devices exhibit robust unipolar resistive switching, low insertion loss, and high isolation across 10–110 GHz.
Tomás Mingates +15 more
wiley +1 more source