Results 51 to 60 of about 4,287,422 (287)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Problemy Ekorozwoju, 2016 The article’s purpose is to present, in the first place, mutual dependences between theoretical and practical speculations concerning urban space, shaped on the base of the sustainable development principle, difficult to implement in practice. Secondly,
Marcin Leźnicki, Aleksandra Lewandowska
doaj
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Derrière l’utopie du jardin collectif, la complexité d’un projet social, technique et politique
Géographie et Cultures, 2017 While community and allotment gardens can be handled as low cost settlements, as a spontaneous movement of citizens who re-appropriate urban spaces, or as a naïve political object, this paper shows that projects of collective gardens actually refer to a ...
Perrine Vandenbroucke +9 more
doaj +1 more source
Development of Green Open Space Policy in The Order to Realize A Sustainable City in Malang
Publik, 2021 The current massive industrial development in urban areas that is not balanced with reforestation practices will have an impact on the environment such as air pollution, hot environmental conditions, flooding, and the lack of adequate Green Open Space ...
Switsa Cellindita +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Urban Echoes: Exploring the Dynamic Realities of Cities through Digital Twins
LandDigital twins (DTs) are highly valuable tools for urban planning as they provide a virtual replica of the physical city, integrating real-time data and simulations to enhance the decision-making and management processes.
Piero Boccardo +2 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source