Results 51 to 60 of about 5,489,015 (279)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Contemporary Concepts of a City in the Context of Sustainable Development: Perspective of Humanities and Natural Sciences

Problemy Ekorozwoju, 2016
The article’s purpose is to present, in the first place, mutual dependences between theoretical and practical speculations concerning urban space, shaped on the base of the sustainable development principle, difficult to implement in practice. Secondly,
Marcin Leźnicki, Aleksandra Lewandowska
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Derrière l’utopie du jardin collectif, la complexité d’un projet social, technique et politique

Géographie et Cultures, 2017
While community and allotment gardens can be handled as low cost settlements, as a spontaneous movement of citizens who re-appropriate urban spaces, or as a naïve political object, this paper shows that projects of collective gardens actually refer to a ...
Perrine Vandenbroucke, Marine Canavese, Brice Dacheux‑Auzière, Marie Grenet, Laure Mouhot, Nathalie Berthier, Gil Melin, Cyril Pouvesle, Élisabeth Rémy, Jean-Noël Consalès   +9 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Development of Green Open Space Policy in The Order to Realize A Sustainable City in Malang

Publik, 2021
The current massive industrial development in urban areas that is not balanced with reforestation practices will have an impact on the environment such as air pollution, hot environmental conditions, flooding, and the lack of adequate Green Open Space ...
Switsa Cellindita, Ach Apriyanto Romadhan, Ali Roziqin   +2 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Urban Echoes: Exploring the Dynamic Realities of Cities through Digital Twins

Land
Digital twins (DTs) are highly valuable tools for urban planning as they provide a virtual replica of the physical city, integrating real-time data and simulations to enhance the decision-making and management processes.
Piero Boccardo, Luigi La Riccia, Yogender Yadav   +2 more
doaj   +1 more source

Aligning Global Urban Planning Trends with Local Challenges: A Citizen-Centered Framework for Functional and Morphological Residential Zones in Port Said, Egypt [PDF]

JES: Journal of Engineering Sciences
Rapid urbanization is intensifying pressures on cities to improve livability and service provision, particularly in intermediate cities such as Port Said, Egypt.
Eman Farrag, Osama Abou El-Einen, Reem Abd El-raouf, Heba Ahmed   +3 more
doaj   +1 more source