Results 31 to 40 of about 113,952 (258)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An Auto-Extraction Framework for CEP Rules Based on the Two-Layer LSTM Attention Mechanism: A Case Study on City Air Pollution Forecasting

Energies, 2022
Energy is at the center of human society and drives the technologies and overall human well-being. Today, artificial intelligence (AI) technologies are widely used for system modeling, prediction, control, and optimization in the energy sector.
Yuan Liu, Wangyang Yu, Cong Gao, Minsi Chen   +3 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Street Verge in Transition: A Study of Community Drivers and Local Policy Setting for Urban Greening in Perth, Western Australia

Urban Science, 2022
The United Nations’ Sustainable Development Goals (SDGs) are regarded as the key policy agenda for national, regional, and local government to combat climate change impacts and promote sustainable development.
Shania Hunt, Jeremy Maher, Mohammad Shahidul Hasan Swapan, Atiq Zaman   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Contemporary Concepts of a City in the Context of Sustainable Development: Perspective of Humanities and Natural Sciences

Problemy Ekorozwoju, 2016
The article’s purpose is to present, in the first place, mutual dependences between theoretical and practical speculations concerning urban space, shaped on the base of the sustainable development principle, difficult to implement in practice. Secondly,
Marcin Leźnicki, Aleksandra Lewandowska
doaj  

An Assessment Model for Sustainable Cities Using Crowdsourced Data Based on General System Theory: A Design Science Methodology Approach

Smart Cities, 2023
In the quest to understand urban ecosystems, traditional evaluation techniques often fall short due to incompatible data sources and the absence of comprehensive, real-time data.
Usman Ependi, Adian Fatchur Rochim, Adi Wibowo   +2 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Derrière l’utopie du jardin collectif, la complexité d’un projet social, technique et politique

Géographie et Cultures, 2017
While community and allotment gardens can be handled as low cost settlements, as a spontaneous movement of citizens who re-appropriate urban spaces, or as a naïve political object, this paper shows that projects of collective gardens actually refer to a ...
Perrine Vandenbroucke, Marine Canavese, Brice Dacheux‑Auzière, Marie Grenet, Laure Mouhot, Nathalie Berthier, Gil Melin, Cyril Pouvesle, Élisabeth Rémy, Jean-Noël Consalès   +9 more
doaj   +1 more source