Results 121 to 130 of about 3,268,438 (293)
Sustainable economic development : concept, principles and management from Islamic perspective [PDF]
, 2010 The basic concern of development in Islamic economic system is on human welfare. This is in line with the very basic objective of Islamic jurisprudence (Shari’ah ) which puts important to the welfare of the people and their relief from hardship. Economic
Ab Rahman, Asmak +2 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A high temporal resolution global gridded dataset of human thermal stress metrics
Scientific DataThe human thermal stress indices and datasets are vital for promoting public health and reducing negative environmental impacts as global climate change and extreme meteorological events increase.
Hongdeng Jian +12 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Riverine communities in the Central Amazon are largely subject to erosion and sedimentation risk
Communications Earth & EnvironmentSedimentary processes cause large changes in riverscapes and alter river banks and margins, leading to major hazards for riverine communities. However, regional mapping of the resulting risk remains scarce, especially in remote Amazon regions.
André Zumak +6 more
doaj +1 more source
Global environmental change and sustainable development [PDF]
, 2008 The UC3M group of “Global environmental change and sustainable development: social trends and emerging policies” offers its experience on the following fields: • Sustainable Development. • Environmental Education. • Agenda 21.
Pardo Buendía, Mercedes
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source