Results 91 to 100 of about 256,469 (301)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Sustainable development from millennium 2015 to sustainable development goals 2030 [PDF]

open access: yes, 2019
In modern economies, the advancement of well‐being of the citizens should be in an inclusive and sustainable way. In this respect, the sustainable welfare targets should exclusively include three main pillars: economic growth, social inclusion, and ...
Halisçelik, E.   +3 more
core   +1 more source

Inconsistent Diurnal Patterns of Far-Red Solar-Induced Chlorophyll Fluorescence Retrieved with Different Algorithms from Tower-Based Observations

open access: yesJournal of Remote Sensing
Tower-based solar-induced chlorophyll fluorescence (SIF) measurements have yielded crucial datasets for investigating the diurnal patterns of SIF and its relationship with vegetation photosynthesis.
Xinjie Liu   +3 more
doaj   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

An Object-Based Approach to Extract Aquaculture Ponds with 10-Meter Resolution Sentinel-2 Images: A Case Study of Wenchang City in Hainan Province

open access: yesRemote Sensing
Coastal aquaculture has made an important contribution to global food security and the economic development of coastal zones in recent decades. However, it has also damaged these coastal zones’ ecosystems.
Yingwen Hu   +3 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Islamic Infrastructure Finance and Sustainable Development Goals [PDF]

open access: yes, 2016
This was a very interesting discussion with the pioneers of Islamic finance regarding infrastructure finance and the sustainable development ...
Moqbel, T.
core  

A Comprehensive Assessment of the Pansharpening of the Nighttime Light Imagery of the Glimmer Imager of the Sustainable Development Science Satellite 1

open access: yesRemote Sensing
The Sustainable Development Science Satellite 1 (SDGSAT-1) satellite, launched in November 2021, is dedicated to providing data detailing the “traces of human activities” for the implementation of the United Union’s 2030 Agenda for Sustainable ...
Hui Li   +3 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

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