Results 231 to 240 of about 503,711 (309)

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Housing modifications for heat adaptation, thermal comfort and malaria vector control in rural African settlements. [PDF]

Nat Med
Abong'o B, Kwaro D, Bange T, Moshi V, Simwero J, Otima J, Mendt S, Ochomo E, Maggioni MA.   +8 more
europepmc   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Regulations Enforcement Mechanisms for Sustainable Housing Projects

Journal of Engineering, 2017
Sawsan Rasheed Mohammed, Ass. Prof. Dr., Ibtisam Abduljabbar Abdulridha, PhD. student   +1 more
doaj  

'A successful re-blocking project is when the government works hand in hand with the community': Factors determining the longevity of re-blocking projects for fire-risk reduction. [PDF]

Jamba
Sintu SS, Pharoah R.
europepmc   +1 more source

B4GALNT4‐Mediated Glycosylation of PDK1 Activates the PI3K‐AKT Signaling Pathway to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
This study identifies B4GALNT4 as a key driver of prostate cancer (PCa). It shows that B4GALNT4 glycosylates PDK1 protein at the N531 site, which stabilizes the PDK1 and constitutively activates the PI3K‐AKT pathway. This mechanism promotes tumor cell proliferation, migration, and invasion. The findings establish the B4GALNT4‐PDK1 glycosylation axis as
Shaoqin Jiang, Mengqiang Li, Qingfu Su, Ruiling Dou, Shaoshan Lin, Jili Zhang, Xiaochen Sun, Haolan Yu, Wei Bao, Min Qu, Yan Wang, Chenghua Yang, Xu Gao   +12 more
wiley   +1 more source

Organic Pig Farming in Europe: Pathways, Performance, and the United Nations Sustainable Development Goals (SDGs) Agenda. [PDF]

Animals (Basel)
Papatsiros VG, Kamvysi K, Fotos L, Tsekouras N, Meletis E, Spilioti M, Gougoulis D, Trachalaki T, Tsatsa A, Papakonstantinou GI.   +9 more
europepmc   +1 more source

Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy

Advanced Science, EarlyView.
Autoantibodies against fibroblast growth factor receptor 3 (FGFR3) are identified as pathogenic drivers of pain in small fiber neuropathy. By binding to sensory neurons in dorsal root ganglia, FGFR3 autoantibodies activate MAPK signaling and induce hyperexcitability and mechanical hypersensitivity, establishing FGFR3 autoantibodies as a therapeutic ...
Lyuba Y. Salih, Nicolas L.A. Dumaire, Clémence Gieré, Erin Vest, Haya Alkhateeb, Christian P. Moritz, Yannick Tholance, Jean‐Philippe Camdessanché, Jean‐Christophe Antoine, Jérôme Honnorat, Jafar Kafaie, Liberty François‐Moutal, Aubin Moutal   +12 more
wiley   +1 more source

One Health Perspective on Antimicrobial Resistance in Bovine Mastitis Pathogens-A Narrative Review. [PDF]

Antibiotics (Basel)
Dhital B, Pudasaini R, Hsieh JC, Pudasaini R, Chen YT, Chao DY, Chiang HI.   +6 more
europepmc   +1 more source

Understanding Food and Nutrition Insecurity Among College Students: Evidence from a Cross-Campus Study. [PDF]

Nutrients
Niroula K, Abdul Razak S, Kalinowski J, Blackman Carr LT, Gorin A, Cooksey Stowers K.   +5 more
europepmc   +1 more source