Results 51 to 60 of about 503,711 (309)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

A Proposal for Desert House Design in Egypt Using Passive Ground Cooling Techniques

open access: yesRenewable Energy and Sustainable Development, 2018
An area less than 5.5% of Egyptian territory is where most of Egypt‘s population lives in. A narrow strip of land forms the Nile Valley and Delta sector.The National Project for Desert Hinterlands is one of the urban projects targeting rehabilitation of ...
Mohamed Medhat Dorra   +2 more
doaj   +1 more source

The PUSH Green Development Zone, Building Housing Equity from the Ground Up [PDF]

open access: yes, 2017
2008 marks the year that PUSH Buffalo founded the Green Development Zone in Buffalo’s West Side. Encompassing 25 square blocks, the Green Development Zone (GDZ) is an area that PUSH is making more environmentally and economically sustainable.1 PUSH ...
Magavern, Sam
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

Sustainable Housing in the Urban Context: International Sustainable Development Indicator Sets and Housing

open access: yesSocial Indicators Research, 2007
Housing, an essential aspect of quality of life, is also significant for sustainable development (SD). All of the major international statements on SD refer to housing or settlement strategies. However, indicator sets derived from these statements often fail to include good indicators of sustainable housing.
Winston, Nessa   +1 more
openaire   +2 more sources

A Strategic Approach to Building Affordable Housing in Philadelphia [PDF]

open access: yes, 2009
Calls on the city to coordinate affordable housing production subsidies with other public and private investments in order to build sustainable mixed-income neighborhoods with energy-efficient homes, ensuring economic growth and long-term ...
Alan Mallach
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Sustainability and change in the institutionalized commute in Belgium: exploring regional differences [PDF]

open access: yes, 2012
This paper examines regional differences in commute-energy performance in Belgium, and explores their relationships with spatial characteristics such as the distribution of population and housing, the metropolitan influence of the Brussels agglomeration,
Boussauw, Kobe   +5 more
core   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Assessing the value of the housing schemes through the sustainable return of investments : a path towards sustainability-led evaluations? [PDF]

open access: yes, 2017
The New 2016 UN Urban Agenda clearly reaffirms the concept that sustainable cities require intertwined environmental and social sustainability. The United Nations Sustainable Development Goal 11 - Make cities inclusive, safe, resilient and sustainable ...
Bichard   +23 more
core   +3 more sources

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