Results 121 to 130 of about 6,076,403 (347)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Islanders’ Perspectives on Sustainable Living

Island Studies Journal, 2006
An internet forum, supported by the Small Islands Voice initiative, has since 2002 provided a place where islanders from around the world could discuss issues and problems and also learn from the experiences of others. This paper provides a reflective overview of the discussions over the past four years and attempts to identify some specific ...
openaire   +3 more sources

Digital Technology and Social Innovation Promoting a Green Citizenship: Development of the “Go Sustainable Living” Digital Application

Circular Economy and Sustainability, 2021
Eirini Triantafyllidou, A. Zabaniotou
semanticscholar   +1 more source

THE CORRELATION BETWEEN UNEMPOYMENT AND REAL GDP GROWTH.A STUDY CASE ON ROMANIA [PDF]

A sustainable rate of real GDP growth is one of the best ways to promote the rise of living standards. From a neoclassical point of view the underlying factors that affect economic growth are saving, population growth and technological progress ...
Dedu Vasile, Dumitrescu Bogdan Andrei, Enciu Adrian   +2 more
core  

Living labs in architecture : open innovation and co-creation towards a more sustainable architecture and lifestyle [PDF]

, 2014
Living Labs in Architecture can be tools towards a holistic knowledge generation and transmission, using real built environments for user-centred research and innovation as well as collaborative learning at a university campus and beyond.
Masseck, Torsten
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Psychosocial factors associated with physical activity, weight management, and sleep in adults with hip and knee osteoarthritis: a systematic review

BMC Rheumatology
Background Osteoarthritis (OA) is a chronic disease primarily affecting older adults, mainly impacting the hip and knee joints. The increasing prevalence of OA contributes to rising healthcare demands and costs.
Britt van Dongen, Amber Ronteltap, Bastiaan Cijs, Corelien Kloek, Catherine Bolman, Rik Crutzen   +5 more
doaj   +1 more source

Wales transport strategy : a consultation [PDF]

, 2012
Sustainable Development Commission response to the 'One Wales : connecting the nation : the Wales transport strategy'. Issues raised include road pricing, biofuels, intra Wales air link, increased capacity on the M4, and living within environmental ...
Sustainable Development Commission Wales
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Experiential and Project-based Learning in BIM for Sustainable Living with Tiny Solar Houses☆

, 2016
The tiny house movement represents a unique building initiative that aims to reduce the environmental and financial impacts of modern living. This paper introduces the integration of a tiny house competition project into an undergraduate construction ...
Wei Wu, B. Hyatt
semanticscholar   +1 more source