Results 141 to 150 of about 6,076,403 (347)
The experiment in living [PDF]
This article engages with debates about widening participation in social research by examining a specific form of public action and knowledge, namely experiments in sustainable living. I propose that these experiments may be approached as forms of social
Marres, Noortje
core
Methodological Framework for implementing and evaluating Living Labs [PDF]
, 2008 A Living Lab constitutes a research approach for innovation that challenges the whole research and innovation process in real-life conditions by human, social, cultural, organizational and institutional aspects having an impact on sustainable service ...
García Guzmán, Javier
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Commentary: The environmental crisis. Who is responsible?
Town and Regional PlanningThe environmental crisis is a substantiated reality, prompting discourse regarding potential solutions. This study undertakes an analysis of literature dating back to the mid-20th century.
Leon Hugo , Jean Hugo Tshwane
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Pollution and Sustainable Living
Journal of Ecological Society, 1994 The keynote address by Prakash Gole discusses pollution and sustainable living in the context of an environmental seminar. The speaker highlights the complexities of pollution and its impact on the environment, economy, and society. The speech underscores the need for awareness and action to address pollution issues, particularly those arising from ...
openaire +1 more source
How can Organic Agriculture contribute to Sustainable Development? [PDF]
, 2006 Organic agriculture can, especially in poorer countries, contribute to meaningful socioeconomical and ecologically sustainable development. On the one hand, this is due to the organic practice, which means management of local resources (e.g.
Kilcher, Lukas
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source