Results 151 to 160 of about 6,076,403 (347)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Commitment to Equity Assessment (CEQ): A Diagnostic Framework to Assess Governments' Fiscal Policies Handbook [PDF]

Fiscal policy can change poverty and inequality substantially or slightly depending on the government's redistributive effort. We develop a diagnostic framework to assess how aligned fiscal policies are with supporting a minimum living standard and human
Nora Lustig
core   +3 more sources

GoWell East Headline Indicators Comparison Report [PDF]

, 2015
This report outlines results for our GoWell East study within four separate chapters, that are focused on the Scottish Government, Commonwealth Games legacy themes: 1) Active; 2) Flourishing; 3) Sustainable; and 4) Connected. Results are presented for
Clark, Julie, Cleland, Claire, Ellaway, Anne, Kearns, Ade, Stewart, Sally   +4 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Piggy Solution: Harnessing Food Waste for Sustainable Hog Farming

Global Challenges
The increasing global population and concomitant rise in food demand lead to significant challenges in sustainable agricultural practices and food waste management.
Matthew C. Ogwu, Catherine E. Hills, Silvana Pietrosemoli   +2 more
doaj   +1 more source

Building envelope design as a contribution for improvement of urban spaces and social housing environmental quality [PDF]

, 2008
The design of building envelope and the definition of its elements, can influence both the quality of the external spaces perception and the living standard referred to internal building spaces. This improvement depends by the planning of some component
ARBIZZANI, Eugenio, CIVIERO, PAOLO, CLEMENTE, Carola, PIERMATTEI P.   +3 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Rapid and deep diesel desulfurization using bimetallic Cu-Fe/TiO2 nano-photocatalysts optimized by response surface methodology

Next Nanotechnology
Sulfur compounds in diesel fuel pose environmental and industrial challenges, necessitating effective removal methods. In this study, a bimetallic Cu-Fe/TiO2 nano-photocatalyst was developed for the photooxidation of dibenzothiophene (DBT) in model ...
Hayyiratul Fatimah Mohd Zaid, Mohd Faridzuan Majid, Nur Ain Atiqah Mohd Amin, Siti Musliha Mat Ghani   +3 more
doaj   +1 more source

Penilaian tahap kelestarian hidup menggunakan konsep POE (sebagai alat pengukuran) di apartment kediaman kerajaan Putrajaya [PDF]

, 2010
Research is done due to the rise of numbers of complaint on defects and damages in the government quarters. The motive of this research is to measure the satisfaction level of the tenants on their sustainable living, the quality of the apartment and the ...
Mohamed Shafie, Anita
core