Results 41 to 50 of about 281,676 (262)

Model-based estimation of pesticides and transformation products and their export pathways in a headwater catchment [PDF]

Hydrology and Earth System Sciences, 2013
Pesticides applied onto agricultural fields are frequently found in adjacent rivers. To what extent and along which pathways they are transported is influenced by intrinsic pesticide properties such as sorption and degradation.
M. Gassmann, C. Stamm, O. Olsson, J. Lange, K. Kümmerer, M. Weiler   +5 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Dead Matter, Living Machines: Repurposing Crustaceans' Abdomen Exoskeleton for Bio‐Hybrid Robots

Advanced Science
Bio‐hybrid robots utilize living organisms for robot design, however, their use of living bodies makes maintenance, control, and fabrication of robot challenging. As an alternative, exoskeletons stand out for retaining mobility after the organism's death,
Sareum Kim, Kieran Gilday, Josie Hughes
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Sky cooling for LED streetlights

Light: Science & Applications
Thermal management is a critical challenge for semiconductor light-emitting diodes (LEDs), as inadequate heat dissipation reduces luminous efficiency and shortens the devices’ lifespan.
Saichao Dang, Hasan H. Almahfoudh, Abdulrahman M. Alajlan, Hussam Qasem, Jiake Wang, Yingkun Zhu, Osman M. Bakr, Boon S. Ooi, Qiaoqiang Gan   +8 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Stainable Utilization Strategies for Basic Oxygen Furnace Slag: Properties, Processing, and Future Directions

Metals
Steel slag, being the dominant solid byproduct in steelmaking, presents global challenges in sustainable management, particularly regarding resource recovery of Basic Oxygen Furnace (BOF) slag, which accounts for over 72% of total slag generation ...
Chunting Ma, Siqi Zhang, Keqing Li, Tong Zhao, Qingxin Meng, Dongshang Guan, Ao Zhang   +6 more
doaj   +1 more source

Recycling of Cooking Oil Waste into Reactive Polyurethane for Blending with Thermoplastic Polyethylene

International Journal of Polymer Science, 2015
Driven by the need of growing to a more sustainable and environmentally friendly future, this research is started by mixing in-house produced biorenewable polymers (BP) from waste cooking oil with the standard low density polyethylene (LDPE) and high ...
Anika Zafiah M. Rus, N. Syamimi M. Salim, N. Haiza Sapiee   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source