Results 221 to 230 of about 40,764 (307)

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Optimal nutritional support is key to liberation from mechanical ventilation. [PDF]

Crit Care Sci
Rosa S, Lassola S.
europepmc   +1 more source

“Guidelines” for sustainable rehabilitation of the rural architecture [PDF]

, 2014
openaire   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Higher job exposures are associated with reduced return-to-work two years after rehabilitation in a nationwide cohort study based on German Pension Insurance data. [PDF]

Sci Rep
Brünger M, Gellert P.
europepmc   +1 more source

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

SPINE20 recommendations 2025: Sustainable spine care for all. [PDF]

Brain Spine
Vlok AJ, Tamai K, Alassiri SS, Blattert TR, Campello MA, Dunn RN, Kamra K, Kitamura K, Roberts LC, Ruosi C, Theron FDV, Tucci C, Yurac R, Bromfield B, Chihambakwe M, Louw QA, Lubbe D, Oosthuizen A, Bussières A, Chhabra HS, Côté P, Costanzo G, Darwono B, Haldeman S, Larouche JS, Muehlbauer EJ, Van Lerbeirghe JG, Alsobayel HI, Franke J, Pereira P, Piccirillo M, Wadhwa S, Wiechert K, Andújar ALF, Carelli LE, Cristante AF, Menezes CM, Meves R, Rodrigues LM, Risso-Net MI, AlEissa S.   +40 more
europepmc   +1 more source

Advancing Sustainable Pulmonary Rehabilitation in Latin America.

Colombia medica (Cali, Colombia)
Benavides-Cordoba, Vicente, Casas Herrera, Alejandro   +1 more
openaire   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Effectiveness and Implementation of Physical Activity Interventions for Rural Breast Cancer Survivors: A Systematic Review. [PDF]

Cureus
Ohta R, Fujimori T, Tanaka K, Hayashi H.
europepmc   +1 more source