Results 111 to 120 of about 60,820 (243)

Growth trends and sustainability yield index of potato in Madhya Pradesh

International Journal of Statistics and Applied Mathematics
Lokesh Kumar, SS Guatam, Aman Karun Ekka, Dheerendra Kumar   +3 more
openaire   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Corrigendum: Effects of varied nutrient regimes on soil health and long-term productivity in a rice–wheat system: insights from a 29-year study in the mollisols of the Himalayan Tarai region

Frontiers in Sustainable Food Systems
Manoj Kumar Bhatt, D. K. Singh, K. P. Raverkar, Ramesh Chandra, Navneet Pareek, Prithwiraj Dey, Prithwiraj Dey, Biswajit Pramanick, Biswajit Pramanick, Hem Chandra Joshi, Mukesh Kumar, Ahmed Gaber, Amnah Mohammed Alsuhaibani, Akbar Hossain   +13 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Global determinants of yield variability under sustainable farming approaches across climate, soil, and topography. A meta-analysis. [PDF]

Agron Sustain Dev
Hounkpatin KOL, Piipponen J, De Giorgi E, Jalava M, Poelert J, Kummu M.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Effect of biochar and mineral fertilizer integration on growth and nutrient dynamics of rice varieties under dry direct-seeded conditions. [PDF]

Front Plant Sci
Mbelle HP, Manhas S, Meya AI, Mabagala FS, Sahoo C, Saini A, Nyoni RM, Abouleish MY, Elbeltagi A.   +8 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Physiological Ecology and Regulation of High-Yield Maize Cultivation. [PDF]

Plants (Basel)
Gu W, Li J.
europepmc   +1 more source