Results 311 to 320 of about 601,429 (390)

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

Anchor Repair of Biceps Femoris Repair Is Similar to Knotless Tunnel Repair in Laboratory Conditions. [PDF]

Orthop J Sports Med
Detweiler B, Jordan SE, Ostrander RV, Truett J, Parry D, Colbrunn G, Anz A.   +6 more
europepmc   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Arthroscopic Management of Posterior Cruciate Ligament Avulsion Fractures Utilizing Anterior Compartment Loop-and-Tack Suspension Fixation. [PDF]

Orthop J Sports Med
Ouyang J, Hui M, Lu J, Jiang C, Guo W.
europepmc   +1 more source

Stama-related variceal bleeding: An under-recognized complication of biliary atresia [PDF]

, 1988
Rowe, MI, Smith, S, Starzl, TE, Wiener, ES   +3 more
core  

Suture stent insertion into an over draining tube shunt lumen via single paracentesis

Sukriti Mohan, Jessie Wang, Jessie Wang, Jonathan Eisengart   +3 more
openalex   +1 more source

Arthroscopic Four-Quadrant Cross-Suture Fixation Using Mini-Tunnels for Tibial Avulsion Fractures of the Anterior Cruciate Ligament. [PDF]

Arthrosc Tech
Peng Y, Wang H, Li Y, Meng C, Yang W, Huang W.   +5 more
europepmc   +1 more source

Biomechanical Investigations of a New Model Graft Attachment to Distal Phalanx in Two-Stage Flexor Tendon Reconstruction. [PDF]

J Clin Med
Mazurek T, Żerdzicki K, Napora J, Ceynowa M.   +3 more
europepmc   +1 more source

A helix tacking system for the management of colonic anastomotic dehiscence, after a laparoscopic left colectomy. [PDF]

Endoscopy
VandenDriessche V, Kaya E, Yengue P, Lefebvre M.   +3 more
europepmc   +1 more source

A Biomechanical Comparison of Patellar Fixation Techniques in Medial Patellofemoral Ligament Reconstruction. [PDF]

Orthop J Sports Med
Martin S, Fuller SI, Ehrensberger MT, Caiola M, Martin E, Bisson LJ.   +5 more
europepmc   +1 more source