Results 271 to 280 of about 161,214 (307)

Dnmt1 Alleviates S1PR1‐Mediated Pyroptosis after Spinal Cord Injury through Regulating Pon3 Expression

Advanced Science, EarlyView.
This study systematically explores the action mechanism of Pon3 and its regulatory targets in spinal cord injury (SCI). It demonstrates that Dnmt1 regulates Pon3 expression by modulating methylation levels, thereby inhibiting S1PR1‐mediated pyroptosis and improving SCI prognosis.
Birong Peng, Haolong Lin, Mi Zhang, Wenhao Kuang, Jiaqi Zhang, Shuai Wang, Yuanfang Sun, Wenning Xu, Lixin Zhu   +8 more
wiley   +1 more source

Surgical outcomes of the closure of mesenteric defects in side-to-side jejunoileal anastomosis plus proximal loop ligation (SSJIBL) using absorbable and non-absorbable surgical sutures. [PDF]

Front Surg
Li Y, Wang J, Wu C, Lu X, Zheng Q, Wei R, Zong Z, Chen Y.   +7 more
europepmc   +1 more source

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

Advanced Science, EarlyView.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang   +17 more
wiley   +1 more source

Biomechanical comparison of suture and screw fixation in PCL avulsion with variable bone quality. [PDF]

Sci Rep
Thamyongkit S, Komonsuwan P, Jitaree B, Aroonjarattham P, Rattanapan N, Somtua C, Saengpetch N.   +6 more
europepmc   +1 more source

A Novel Self‐Regulated, Non‐Directional Magnetic Thermos‐Brachytherapy 125I Seed Enhances Anticancer Efficacy by Rescuing Immune Escape

Advanced Science, EarlyView.
This work constructs magnetic nanoparticles (MNPs) and incorporates them with silver rods coated with 125I to form a novel composite seed, which exhibits direction‐independent and self‐regulated heating efficiency, as well as the capacity of preventing MNPs leakage and enabling repeated hyperthermia.
Bin Xu, Ye‐Ming Wu, Yi‐Fei Cheng, Lei Dong, Shuai‐Wen Ding, Sheng‐Rong Chen, Bin‐Da Chen, Ren‐Peng Yang, Wei‐Hua Zhang, Ya‐Jie Wang, Wei‐Pu Mao, Fan Shi, Zhi‐Cheng Jin, Jian‐Jian Chen, En‐Qi Qiao, Yu‐Qing Wang, Jin‐Ze Li, Peng Zeng, Cheng‐Wei Wu, Wei Zhang, Jin‐Bing Xie, Jian Lu, Gao‐Jun Teng   +22 more
wiley   +1 more source

Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus

Advanced Science, EarlyView.
Multi‐modality imaging strategy applied to PRV‐induced central nervous system infection enables dynamic visualization of cerebrovascular dysfunction, including hyperemia, hypoperfusion, and vascular remodeling. These changes are linked to microglial activation and impaired angiogenesis, providing mechanistic insight into PRV neuropathogenesis and ...
Shuting Ling, Chongxin Wu, Mengxuan Gui, Kaiyun Chen, Yanbo Yang, Jiwei Xing, Fengxian Du, Wei Liao, Luyao Yang, Zhaokui Jin, Ningshao Xia, Guosong Wang, Yixin Chen, Qingliang Zhao   +13 more
wiley   +1 more source

Synergistic Promotion of Triple‐Negative Breast Cancer Tumorigenesis and Metastasis by Oral Polystyrene Nanoplastics Exposure via Alloprevotella‐Derived Glutamate and Platelet Activation

Advanced Science, EarlyView.
Polystyrene nanoplastics (PS‐NPs) administered via oral exposure accelerate triple‐negative breast cancer (TNBC) progression by synergistically modulating gut microbiota‐derived glutamate production and platelet activation. This study uncovers a pivotal crosstalk between microbial metabolites and platelet‐tumor interactions, offering mechanistic ...
Leilei Zhu, Peihao Xu, Mingyuan Zhou, Kewei Li, Shasha Tian, Xuemei Fan, Junling Liu, Baodong Ye, Zhishan Ding, Yingzhi Shen   +9 more
wiley   +1 more source

A Disease-Specific Simulator of the Laparoscopic Percutaneous Extraperitoneal Closure (LPEC) Method for Pediatric Inguinal Hernia: A Validation Study With Comparison of Experienced Pediatric Surgeons and Novices. [PDF]

World J Surg
Murakami M, Tabata Y, Iwamoto Y, Ogata M, Takada L, Kedoin C, Tsuruno Y, Sugita K, Yano K, Onishi S, Kawano T, Ieiri S.   +11 more
europepmc   +1 more source

Short Expandable-Wing Suture Anchor for Osteoporotic and Small Bone Fixation: Validation in a 3D-Printed Coracoclavicular Reconstruction Model. [PDF]

J Funct Biomater
Tsai CH, Huang SF, Lin RC, Lee PW, Lee CY, Lin CL.   +5 more
europepmc   +1 more source

Effect of unilateral arytenoid lateralisation on the rima glottidis volume in cats: a cadaveric study. [PDF]

J Feline Med Surg
Juhász Z, Immler M, Adamik R, Paál G, Mózes B, Krauß M.   +5 more
europepmc   +1 more source