How localized Ca2+ signals orchestrate neural repair remains unclear. Here, we show that TRPC3‐driven calcium microdomains direct nerve repair by coupling spatially confined Ca2+ signals to axon regeneration. This module operates in injured peripheral neurons and correlates with neuroprotection in Parkinson's disease, revealing a spatial logic for ...
Yu Lu +14 more
wiley +1 more source
Wound closure after total knee arthroplasty: Comparison of polypropylene and polyglactin 910 suture-a randomized controlled trial. [PDF]
Khan MA, Mohammad N, Chinoy MA, Khan MD.
europepmc +1 more source
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li +9 more
wiley +1 more source
Arthroscopic-Assisted Combined Superior Capsular Reconstruction and Lower Trapezius Transfer Using Dual Achilles Allografts for Irreparable Posterosuperior Rotator Cuff Tears. [PDF]
Do WS, Chun YM, Kim SJ, Lim JR, Yoon TH.
europepmc +1 more source
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao +12 more
wiley +1 more source
Supercritical CO<sub>2</sub>-Assisted Impregnation of Absorbable Surgical Sutures with Carvacrol and Benzydamine Hydrochloride: Comparative In Vitro Release Profiles and Drug Release Kinetics. [PDF]
Akpınar A +6 more
europepmc +1 more source
Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments
Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang +10 more
wiley +1 more source
Not Every Draining Wound is Infection: Vicryl Reaction after Total Knee Arthroplasty Mimicking Prosthetic Joint Infection - A Case Series and Diagnostic Insights. [PDF]
Sahu A +5 more
europepmc +1 more source

