Results 281 to 290 of about 378,715 (362)

Amelioration of Post‐Stroke Edema and Microcirculatory Dysfunction via Targeted AQP4 Inhibition While Preserving the Glymphatic System

Advanced Science, EarlyView.
Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin, Zeyu Yang, Boyang Wei, Yu Wu, Longxiang Li, Jiaming Zhou, Xin Zhang, Fa Jin, Shixing Su, Yanchao Liu, Ran Li, Shenquan Guo, Xingwu Liu, Yu Cai, Hong Liu, Min Chen, Wenchao Liu, Chuanzhi Duan, Xifeng Li   +18 more
wiley   +1 more source

One-step removal of nasobiliary tube and pancreatic stent with a new linked-stent approach: a green tip to avoid additional procedure. [PDF]

Endoscopy
Tao R, Chen C, Liu J, Ou X, Zhang L, Liu D.   +5 more
europepmc   +1 more source

Dual‐Anchored Clickable Peptide via SPAAC for Gelatinase‐Responsive Antibacterial and Osteogenic Functions on Titanium Implants

Advanced Science, EarlyView.
To address the infection‐associated orthopedic implant failures, this study presents a gelatinase‐responsive antibacterial titanium implant (Ti‐Dual) featuring a dual‐anchored fusion peptide containing antibacterial (HHC36) and osteogenic (RGD) domains connected by a cleavable GPLGV linker.
Ru Zhong, Hang Zhou, Chenyang Ye, Lei Chu, Lin Wang, Yingjun Wang   +5 more
wiley   +1 more source

Pedicled Anterior Cruciate Ligament Reconstruction and Lateral Extra-articular Tenodesis Without Additional Implants-"PARLET" Technique. [PDF]

Arthrosc Tech
Wodzinski P, Zoraw T, Wielgus A, Sadlik B, Dragan S.   +4 more
europepmc   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Arthroscopic Four-Quadrant Cross-Suture Fixation Using Mini-Tunnels for Tibial Avulsion Fractures of the Anterior Cruciate Ligament. [PDF]

Arthrosc Tech
Peng Y, Wang H, Li Y, Meng C, Yang W, Huang W.   +5 more
europepmc   +1 more source

Patellar socket technique for chronic quadriceps tendon repair: maximizing graft efficiency. [PDF]

Arch Orthop Trauma Surg
Porcelli P, Zoccola K, Cambursano S, Giai Via R, Giustra F, Massè A, Capella M.   +6 more
europepmc   +1 more source

Comparative study between combined oblique and vertical everting running stitch and the conventional suturing technique. [PDF]

World J Orthop
Sadiq M, Neerudi SR, Kasam RR, Koribilli SP, Naik VRS, Naik BD, Singh PK, Manne A, Kothalanka UK, Mettu AK, Nunnabatla K, Ale SK, Mallepogu KK, Bebartta SP.   +13 more
europepmc   +1 more source

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Sutures: The Suspension Suture

The Journal of Dermatologic Surgery and Oncology, 1987
Abstract. The suspension suture is a tension‐reducing stitch that anchors the undersurface of a flap or elliptical wound edge to the underlying periosteum. The technique of placing the stitch is described and the indications for and the benefits derived from its use are discussed.
COL STUART J. SALASCHE, LTC ROBERT JARCHOW, CDR BRUCE D. FELDMAN, CPT MARY JOANNE DEVINE‐RUST, LTC JOHN ADNOT   +4 more
openaire   +1 more source