Results 291 to 300 of about 456,239 (386)

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

open access: yesAdvanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo   +10 more
wiley   +1 more source

Novel Quaternary Ammonium Salt‐Linked STING Agonist Antibody‐Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off‐Target Toxicity

open access: yesAdvanced Science, EarlyView.
Novel quaternary ammonium salt‐linked STING agonist ADC demonstrates high potency, stability, enhanced solubility, and reduced off‐target toxicity, potently activating the STING pathway in the tumor microenvironment through the synergistic action of the Fab and Fc regions of antibodies (activity switch‐on) while exhibiting ≈20 fold lower activity in ...
Yu Long   +17 more
wiley   +1 more source

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

open access: yesAdvanced Science, EarlyView.
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei   +11 more
wiley   +1 more source

Economic analysis of triclosan-coated versus uncoated sutures at preventing surgical site infection in patients undergoing abdominal surgery. [PDF]

open access: yesBMJ Surg Interv Health Technol
Kachapila M   +6 more
europepmc   +1 more source

Wearable Bioelectronics for Home‐Based Monitoring and Treatment of Muscle Atrophy

open access: yesAdvanced Science, EarlyView.
As an inevitable disease, muscle atrophy has received more attention. Because the factors that induce this disease are diverse, achieving a complete cure is still impossible. Wearable bioelectronics provides a more comfortable, low‐cost, and efficient way of home care for the monitoring and treatment of muscle atrophy. Therefore, this review summarizes
Shuai Zhang   +4 more
wiley   +1 more source

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