Results 131 to 140 of about 102,062 (333)

The potential clinical implications of slow vital capacity in patients with idiopathic pulmonary fibrosis

open access: yesRespiratory Research
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with a highly variable clinical course. Forced vital capacity (FVC) is widely used as a marker of disease severity and progression, yet its variability and dependence on ...
Ho Cheol Kim   +6 more
doaj   +1 more source

On‐feet isometric bracing maintains cerebral arterial blood velocity during lower body negative pressure via preload augmentation

open access: yesExperimental Physiology, EarlyView.
Abstract Orthostatic stress reduces venous return and stroke volume (SV), risking cerebral hypoperfusion despite autonomic compensation. Although lower‐limb counterpressure manoeuvres improve cerebral perfusion in upright posture, their effects on cerebral blood velocity (CBV) during lower‐body negative pressure (LBNP) and the associated mechanisms are
Jun Sugawara   +5 more
wiley   +1 more source

Structural determinants of re‐entrant drivers in atrial fibrillation: insights from digital twins derived from 3D micrometre‐resolution imaging of human heart

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Digital heart models of human donor atria with cardiac co‐morbidities revealed that regions with AWT variation, aligned myofibres adjacent to disorganised zones and fibrotic borders promoted the localisation and stability of RDs. AWT had a global influence, whereas fibre orientation and fibrosis exerted chamber‐specific regional ...
Anuradha Kulathilaka   +8 more
wiley   +1 more source

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones   +2 more
wiley   +1 more source

The Evaluation of Machine Learning Models Using Matrix‐Assisted Laser Desorption/Ionization Time‐of‐Flight Mass Spectrometry (MALDI–TOF–MS) Spectra for the Prediction of Antibiotic Resistance in Klebsiella pneumoniae

open access: yesMicrobiologyOpen, Volume 15, Issue 2, April 2026.
Machine learning models developed from matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry spectra can rapidly predict antimicrobial resistance in Klebsiella pneumoniae. By transforming routine spectral data into accurate resistance profiles within minutes, this approach could reduce diagnostic delays and support earlier ...
Stephen Mark Edward Fordham
wiley   +1 more source

Superior Vena Cava Syndrome due to Thrombosis: A Rare Paraneoplastic Presentation of Bronchogenic Carcinoma

open access: yesIranian Journal of Medical Sciences, 2016
Superior vena cava (SVC) syndrome is not an uncommon occurrence in patients with malignancy and it is often described as a medical emergency. In majority of the cases, SVC syndrome occurs due to mechanical obstruction of the SVC by extraluminal ...
Avradip Santra   +3 more
doaj  

Association between serum vitamin C and body mass index in adolescents aged 12–19 years

open access: yesBMC Public Health
Background Evidence on the association between serum vitamin C (sVC) levels and obesity is limited. This study aimed to explore the relationship between sVC and body mass index (BMI) in adolescents aged 12 to 19 years.
Xiaoqi Su   +6 more
doaj   +1 more source

Phase 3b Extension Study MT‐1186‐A04 to Evaluate the Continued Efficacy and Safety of Edaravone Oral Suspension for Up to an Additional 48 Weeks in Patients With Amyotrophic Lateral Sclerosis

open access: yesMuscle &Nerve, Volume 73, Issue 4, Page 534-543, April 2026.
ABSTRACT Introduction/Aims An On/Off dosing regimen of intravenous (IV) edaravone and edaravone oral suspension is currently approved in the US for treatment of amyotrophic lateral sclerosis (ALS). Placebo‐controlled clinical trials showed that IV edaravone slows physical functional decline.
Angela Genge   +17 more
wiley   +1 more source

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