Results 181 to 190 of about 129,793 (292)

Stabilizing Plasmodium falciparum proteins for small molecule drug discovery

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Early‐stage drug discovery relies on the availability of stable protein for reliable biophysical characterization of ligand binding. However, many Plasmodium falciparum proteins are challenging to produce in heterologous systems, which limits their experimental utility.
Marius Amann, Tim Sträßer, Oliver Einsle, Stefan Günther   +3 more
wiley   +1 more source

Carotid arteries in cerebral small vessel disease and dementia. [PDF]

Acta Neuropathol Commun
Kitajima E, Suwanda A, Jobson D, Allan L, Paydar K, Han G, Washida K, Ihara M, Kalailingam P, Hase Y, Sze SK, Polvikoski T, Kalaria RN.   +12 more
europepmc   +1 more source

On the Foundational Arguments of Sufficient Dimension Reduction

WIREs Computational Statistics, Volume 18, Issue 2, June 2026.
Contemporary Sufficient Dimension Reduction, a versatile method for extracting material information from data, can serve as a preprocessor for classical modeling and inference, or as a standalone theory that leads directly to statistical inference. ABSTRACT Sufficient dimension reduction (SDR) refers to supervised methods of dimension reduction that ...
R. Dennis Cook
wiley   +1 more source

Small-vessel Disease in a Patient with Atrial Flutter: Unveiling a Potential Vascular Mechanism of Tachycardia-induced Cardiomyopathy. [PDF]

J Innov Card Rhythm Manag
Weyand S, Klingel K, Seizer P.
europepmc   +1 more source

Text Mining in Bibliometrics and Science Mapping: A Methodological Review

WIREs Computational Statistics, Volume 18, Issue 2, June 2026.
Text mining has become a foundational component of contemporary bibliometrics and science mapping, enabling systematic analysis of the semantic structure, thematic evolution, and cognitive organization of scientific fields. Integrating textual evidence with relational indicators enriches knowledge maps and supports more comprehensive, content‐sensitive
Michelangelo Misuraca
wiley   +1 more source

NOTCH3 Pathogenic Variant and Risk of Age-Related Macular Degeneration: Findings From the Taiwan Biobank and Small Vessel Disease Registry. [PDF]

Invest Ophthalmol Vis Sci
Chen CH, Lin CW, Wu SH, Yang ZW, Lin CW, Shen YC, Cheng YW, Su MW, Tang SC.   +8 more
europepmc   +1 more source

Fetal Cardiac Function in Early Labour and Intrapartum Outcomes: A Prospective Observational Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 7, Page 1414-1423, June 2026.
ABSTRACT Objective To assess fetal myocardial deformation in normo‐oxygenated foetuses in early labour and its relationship with intrapartum outcomes. Design Single centre prospective study. Setting Referral tertiary maternity unit. Population Uncomplicated singleton term pregnancies in early labour. Methods Two‐dimensional (2D) ultrasound clips of the
Andrea Dall'Asta, Chiara Melito, Beatrice Valentini, Mariagrazia Capurso, Maria Teresa Baffa, Olga Patey, Basky Thilaganathan, Tullio Ghi   +7 more
wiley   +1 more source

Microscopic ligation combined with shunt procedure versus microsurgical varicocelectomy for nutcracker syndrome and left varicocele: a randomized controlled trial. [PDF]

Basic Clin Androl
Dou K, Zeng X, Yang Q, Li Y, Wang L, Song T, Yao J.   +6 more
europepmc   +1 more source

Positioning of Melflufen in Heavily Pretreated RRMM Patients: Real‐World Evidence in a Rapidly Evolving Therapeutic Landscape

European Journal of Haematology, Volume 116, Issue 6, Page 928-936, June 2026.
ABSTRACT Modern therapies have clearly marked the history of multiple myeloma (MM), leading to undisputed advantages in terms of sustained responses and prolonged survival, while progressively improving patients' quality of life. Nonetheless, disease recurrence and resistance to available therapies underscore the importance of identifying additional ...
K. Mancuso, S. Masci, M. Talarico, A. Vitale, S. Barbato, V. Solli, M. Puppi, I. Rizzello, L. Pantani, P. Tacchetti, M. Iezza, R. Restuccia, I. Sacchetti, E. Manzato, S. Ghibellini, S. Armuzzi, B. Taurisano, M. Cavo, E. Zamagni   +18 more
wiley   +1 more source

Retinal thickness and microvascular alterations in the diagnosis of behcet's disease: a case-control study. [PDF]

BMC Med Imaging
Xing ZM, Chen C, Zhong L, Hu JY, Zeng YM, Wang XY, He LQ, Ge QM, Ling Q, Chen X, Wang YX, Shao Y.   +11 more
europepmc   +1 more source