Results 101 to 110 of about 442,254 (313)

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Data‐Driven Feedback Identifies Focused Ultrasound Exposure Regimens for Improved Nanotheranostic Targeting of the Brain

Advanced Science, EarlyView.
ABSTRACT The blood‐brain barrier (BBB) renders the delivery of nanomedicine in the brain ineffective and the detection of circulating disease‐related DNA from the brain unreliable. Here, we demonstrate that microbubble‐enhanced focused ultrasound (MB‐FUS) mediated BBB opening, supported by large‐data models predict sonication regimens for safe and ...
Hohyun Lee, Victor Menezes, Shiqin Zeng, Chulyong Kim, Cynthia M. Baseman, Jae Hyun Kim, Samhita Padmanabhan, Pranav Premdas, Naima Djeddar, Anton Bryksin, Nikhil Pandey, Pavlos Anastasiadis, Anthony J. Kim, Tobey J. MacDonald, Chetan Bettegowda, Graeme F. Woodworth, Felix J. Herrmann, Costas Arvanitis   +17 more
wiley   +1 more source

A Tangentially Sensitive Tactile Sensor Reveals the Stick‐Slip Mechanism and Enhances Robotic Tactile Sensing

Advanced Science, EarlyView.
An ultralight, multilayer anisotropic tactile sensor—an artificial Pacinian corpuscle—exhibits ultrahigh tangential sensitivity (1022 kPa−1) and spatiotemporal sensing. It discriminates static, sliding, and rolling contacts, detects incipient stick–slip via high‑frequency signatures, and enhances robotic touch (100%/98.18% accuracy for active/passive ...
Jinghui Wang, Xiaoyu Liu, Yujiao Du, Yepu Chen, Jieyi Guo, Linyuan Fan, Min Tang, Xiaofeng Qiao, Yuanjie Zhu, Zhiyang Zhang, Chaojie Dong, Lizhen Wang, Yubo Fan   +12 more
wiley   +1 more source

New discrimination diagrams for basalts based on big data research

Big Earth Data, 2019
In recent days, discrimination diagrams have been widely used for tracing the tectonic settings and origins of basalts from orogenic belts. However, conventional discrimination diagrams are not accurate enough.
Qi Zhang, Weidong Sun, Yong Zhao, Fanglin Yuan, Shoutao Jiao, Wanfeng Chen   +5 more
doaj   +1 more source

SVM Communications: Highlights from the 32nd SVM Scientific Sessions [PDF]

Vascular Medicine, 2021
openaire   +2 more sources

Machine Learning‐Enhanced Analysis of Exosomal Surface Sialic Acid Using Surface‐Enhanced Raman Spectroscopy for Ovarian Cancer Diagnosis and Therapeutic Monitoring

Advanced Science, EarlyView.
Machine learning‐assisted surface‐enhanced Raman spectroscopy analysis of exosomal sialic acid for ovarian cancer diagnosis, as well as independent monitoring of exosomal sialic acid expression levels across different treatment periods, reveals a potential correlation with treatment response.
Lili Cong, Jiaqi Wang, Sijun Huang, Xiaxia Man, Yi Guo, Shuping Xu, Songling Zhang   +6 more
wiley   +1 more source

An Intelligent Magneto‐Mechanical Platform for Cellular Sensing in 3D Microenvironments

Advanced Science, EarlyView.
This study presents MagMI, a pioneering machine intelligence‐driven magneto‐mechanical sensing platform. It utilizes magneto‐mechanical arrays and machine learning to achieve label‐free, real‐time monitoring and classification of cellular proliferation dynamics within 3D microenvironments.
Yue Quan, Yuxin Wang, Sen Ding, Bingpu Zhou, Yinning Zhou   +4 more
wiley   +1 more source

SVM Communications: Membership spotlight [PDF]

Vascular Medicine, 2021
Daniella, Kadian-Dodov, Carmel, Celestin, Leben, Tefera, Jeffrey, Olin   +3 more
openaire   +2 more sources

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Prediction of Ki-67 Expression in HIV-Associated Lung Adenocarcinoma Patients Using Multiple Machine Learning Models Based on CT Imaging Radiomics

Cancer Management and Research
Chang Song,1,* Jingsong Chen,2,* Chunyan Zhao,1,* Shulin Song,3,* Tong Yang,4 Aichun Huang,1 Renhao Liu,1 Yanxi Pan,3 Chaoyan Xu,1 Canling Chen,1 Qingdong Zhu1 1Tuberculosis Department, Nanning Fourth People’s Hospital, Nanning, Guangxi ...
Song C, Chen J, Zhao C, Song S, Yang T, Huang A, Liu R, Pan Y, Xu C, Chen C, Zhu Q   +10 more
doaj