Results 111 to 120 of about 613,158 (317)

Interpretable PROTAC Degradation Prediction With Structure‐Informed Deep Ternary Attention Framework

open access: yesAdvanced Science, EarlyView.
PROTAC‐STAN, a structure‐informed deep learning framework is presented for interpretable PROTAC degradation prediction. By modeling molecular hierarchies and protein structures, and simulating ternary interactions via a novel attention network, PROTAC‐STAN achieves significant performance gains over baselines.
Zhenglu Chen   +11 more
wiley   +1 more source

ارزیابی یادگیری ماشین و سنجش از دور در تخمین تبخیر و تعرق مرجع [PDF]

open access: yesمدیریت آب و آبیاری
تبخیر و تعرق مرجع (ETo) یکی از اساسی‌ترین متغیرها در تعیین نیاز آبی محصول و برنامه‌ریزی و طراحی سامانه‌های آبیاری است. مدل‌های یادگیری ماشین برای رفع محدودیت‌های مدل‌های تجربی و برآورد تبخیر تعرق (ET) توسعه داده‌ شده‌اند.
جوانشیر عزیزی مبصر   +2 more
doaj   +1 more source

Overlapping Clustering Models, and One (class) SVM to Bind Them All [PDF]

open access: green, 2018
Xueyu Mao   +2 more
openalex   +1 more source

B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns

open access: yesAdvanced Science, EarlyView.
B‐Epic: Achieving high‐accuracy B cell epitope prediction through Transformer architecture. Comprehensive validation demonstrates B‐Epic's robust performance across diverse datasets. B‐Epic facilitates vaccine development for H. pylori and EBV, addressing critical public health challenges.
Jun‐Ze Liang   +16 more
wiley   +1 more source

Automatic-Detection Method for Mining Subsidence Basins Based on InSAR and CNN-AFSA-SVM [PDF]

open access: gold, 2022
Lei Wang   +6 more
openalex   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

open access: yesAdvanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang   +19 more
wiley   +1 more source

Reprogramming Tumor‐Associated Macrophages via Targeted NAT10 Inhibition to Enhance Colorectal Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
This study presents the sono‐sensitive nanorobot Sono@NAT10, which targets NAT10 condensates to reprogram tumor‐associated macrophages in colorectal cancer. By reducing the acetylation level of SRSF2 protein and activating HDAC10, Sono@NAT10 promotes M1 polarization, suppresses tumor progression, and strengthens immunotherapy. The approach demonstrates
Jiahao Zhu   +11 more
wiley   +1 more source

New discrimination diagrams for basalts based on big data research

open access: yesBig Earth Data, 2019
In recent days, discrimination diagrams have been widely used for tracing the tectonic settings and origins of basalts from orogenic belts. However, conventional discrimination diagrams are not accurate enough.
Qi Zhang   +5 more
doaj   +1 more source

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