Results 131 to 140 of about 191,290 (268)

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

Microbiologically influenced corrosion (MIC) potential of bentonite microorganisms: implications for a deep geological repository for nuclear waste. [PDF]

World J Microbiol Biotechnol
Černá K, Mukhtar SS, Bureš R, Alfaro-Espinoza G, Koerdt A, Říha J, Hlavackova V, Stoulil J.   +7 more
europepmc   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Diagnostic accuracy study of the multiplex Truenat MTB Ultima/COVID-19 assay for simultaneous detection of Tuberculosis and SARS-CoV2 (COVID-19). [PDF]

PLOS Glob Public Health
Tootla H, Székely R, Sserubiri J, Zemanay W, Patidar M, Joloba M, Ugarte-Gil C, Ruhwald M, Purohit M, Cox H, Zamudio C, Ssengooba W, Penn-Nicholson A, COMBO study team.   +13 more
europepmc   +1 more source

Diagnostic Swabs in Pertussis [PDF]

Proceedings of the Royal Society of Medicine, 1955
openaire   +2 more sources

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Diagnostic Accuracy of 2 cm Versus 4 cm Insertion Depth for Nasal Swabs for SARS-CoV-2 Rapid Antigen Testing-A Randomized Controlled Trial. [PDF]

Diagnostics (Basel)
Callesen RE, Todsen T, Eið RC, Stange SD, Gredal T, Kirkby N, Papesch M, von Buchwald C, Jakobsen KK.   +8 more
europepmc   +1 more source

Alternative Swabs [PDF]

The Annals of The Royal College of Surgeons of England, 2006
MA Scott, G Atkin, RJ Foley
openaire   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Relationship Between <i>Clostridioides difficile</i> Stool Concentration, Nucleic Acid Amplification Test Results, and Environmental Contamination. [PDF]

Open Forum Infect Dis
Lee MM, Reske KA, Hink T, Fishbein SRS, Newcomer EP, Cass C, Olsen MA, Dantas G, Burnham CD, Dubberke ER.   +9 more
europepmc   +1 more source