Results 31 to 40 of about 373,485 (288)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LONG-TERM STATISTICS OF STORMS IN THE BALTIC, BARENTS AND WHITE SEAS AND THEIR FUTURE CLIMATE PROJECTIONS

Geography, Environment, Sustainability, 2018
The numerical model simulations of storm activity in the White, Baltic andBarentsSeaswere analyzed for the period from 1979 to2015. Inthis paper the storm number of these seas was calculated.
Stanislav Myslenkov, Alisa Medvedeva, Victor Arkhipkin, Margarita Markina, Galina Surkova, Aleksey Krylov, Sergey Dobrolyubov, Sergey Zilitinkevich, Peter Koltermann   +8 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

I-gel Laryngeal Mask Airway Combined with Tracheal Intubation Attenuate Systemic Stress Response in Patients Undergoing Posterior Fossa Surgery

Mediators of Inflammation, 2015
Background. The adverse events induced by intubation and extubation may cause intracranial hemorrhage and increase of intracranial pressure, especially in posterior fossa surgery patients.
Chaoliang Tang, Xiaoqing Chai, Fang Kang, Xiang Huang, Tao Hou, Fei Tang, Juan Li   +6 more
doaj   +1 more source

An Analysis Method of Black Swan Event based on Impact-spread Tree

Journal of Risk Analysis and Crisis Response (JRACR), 2020
The black swan event has the characteristics of rarity and serious consequences. At present, the analysis of black swan events is generally preconceived (that is, the event is assumed to be a black swan event, and then the influence of the event is ...
Xinying 馨营 Liu 刘, Hang 航 Li 李, Xiaobing 小兵 Hu 胡   +2 more
doaj   +1 more source

Pneumatosis intestinalis: Not always bowel ischemia

Radiology Case Reports, 2022
Pneumatosis intestinalis or abnormal intramural gas within the digestive tract usually suggests bowel ischemia necessitating urgent surgery. We report the case of an 82-year-old female presenting with hypotension and nausea, with a past history of ...
Adele Hwee Hong Lee, MBBS, Shanthapriya Tellambura, MBBS, FRACS   +1 more
doaj   +1 more source

Nearshore wave forecasting and hindcasting by dynamical and statistical downscaling

, 2012
A high-resolution nested WAM/SWAN wave model suite aimed at rapidly establishing nearshore wave forecasts as well as a climatology and return values of the local wave conditions with Rapid Enviromental Assessment (REA) in mind is described. The system is
Birgitte R. Furevik, Booij, Gaslikova, Gaslikova, Hasselmann, Jenkinson, Lopatoukhin, Magnar Reistad, Monbaliu, Naess, Naess, O'Reilly, Ole Johan Aarnes, Reistad, Reistad, Ris, Simiu, Smith, Smith, Stoelinga, Tolman, Unden, Wilks, Wilson, Yvonne Gusdal, Øyvind Breivik   +25 more
core   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Study of the 16S microbiome of swans died during the H5N1 outbreak in the Caspian seashore

Frontiers in Veterinary Science
IntroductionIn 2023 and 2024, mass mortalities of swans occurred on the Caspian coast of Kazakhstan, which affected more than seven hundred birds of a local population of 10–15 thousand.
Kobey Karamendin, Sardor Nuralibekov, Temirlan Sabyrzhan, Yermukhammet Kasymbekov, Symbat Suleymenova, Aidyn Kydyrmanov   +5 more
doaj   +1 more source

Authors and open access publishing [PDF]

, 2004
Surveys were carried out to learn more about authors and open access publishing. Awareness of open access journals among those who had not published in them was quite high; awareness of "self-archiving" wasless.
Brown, Sheridan, Swan, Alma
core   +1 more source