Results 71 to 80 of about 110,510 (299)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The Simple Analytics of Debt-Equity Swaps [PDF]
Recent attempts to resolve the international debt crisis have lead some countries to engage in debt-equity swaps. The paper explores conditions under which such transactions are beneficial to the debtor as well as the creditors.
Elhanan Helpman
core
Improved Bounds for Swap Multicalibration and Swap Omniprediction
CoRRIn this paper, we consider the related problems of multicalibration -- a multigroup fairness notion and omniprediction -- a simultaneous loss minimization paradigm, both in the distributional and online settings. The recent work of Garg et al. (2024) raised the open problem of whether it is possible to efficiently achieve $O(\sqrt{T})$ $\ell_{2 ...
Haipeng Luo +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Imamiah Jurisprudence Perspectives on Commodity Swaps [PDF]
تحقیقات مالی اسلامی (پیوسته), 2013 Nowadays, with the development of financial institutions and the extension of business scope, risk management has found major significance in economic studies. Today, various approaches and tools are designed to manage and reduce different types of risks.
Sayyed Abbas Mousavian +1 more
doaj
Proceedings of the 56th Annual ACM Symposium on Theory of ComputingWe introduce and study swap cosystolic expansion, a new expansion property of simplicial complexes. We prove lower bounds for swap coboundary expansion of spherical buildings and use them to lower bound swap cosystolic expansion of the LSV Ramanujan complexes.
Yotam Dikstein, Irit Dinur
openaire +3 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
In [10] we presented a reduced form of risky bond pricing. At the default date a bond seller fail to continue fulfill his obligation and the price of the bond sharply drops down. If the face value of the defaulted bond for no-default scenarios is $1 then
Gikhman, Ilya
core +4 more sources
Swaps and the swaps yield curve [PDF]
Interest rate swaps have become a popular financial derivative, and market watchers and economists are paying closer attention to them and their associated yield curves.
Joseph G. Haubrich
core
BBR: Brazilian Business Review, 2013 O objetivo deste trabalho é verificar, com base na teoria de equilíbrio de portfólio, qual o impacto das ofertas pelo Banco Central do Brasil dos swaps cambiais e dos swaps cambiais reversos nos atributos referentes à estrutura a termo do cupom cambial ...
Alessandra Pasqualina Viola +3 more
doaj