Results 51 to 60 of about 2,224 (288)

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Característica produtiva e estrutural de pastos mistos de aveia e azevém manejados em quatro alturas sob lotação contínua Structural and productive characteristic of oat and ryegrass mixed pastures managed in four intensities with variable stocking rate

Revista Brasileira de Zootecnia, 2010
Monitoraram-se variáveis relacionadas à produção e à estrutura de pastos de aveia-preta (Avena strigosa, Schreb) e azevém (Lolium multiflorum, Lam) manejados em quatro alturas (10, 20, 30 e 40 cm), em pastejo contínuo com lotação variável (put and take).
Paulo César de Faccio Carvalho, Lemar Maciel da Rocha, Carolina Baggio, Stefani Macari, Taise Robinson Kunrath, Aníbal de Moraes   +5 more
doaj   +1 more source

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

Advanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau   +4 more
wiley   +1 more source

Daily Forage Intake by Cattle on Natural Grassland: Response to Forage Allowance and Sward Structure

, 2016
We investigated the hypothesis that not only forage allowance but also sward structure affects daily forage intake by beef heifers on natural grasslands of the Pampa Biome (southern Brazil).
Bremm, C., Mezzalira, J.C., Carvalho, P.C.F., Gonda, H.L., Neves, F.P., Trindade, J.K.D., Nadin, L.B., Pinto, C.E., Genro, T.C.M.   +8 more
core   +1 more source

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source

Frequencies and intensities of defoliation in Aruana guineagrass swards: morphogenetic and structural characteristics [PDF]

Revista Brasileira de Zootecnia, 2012
The objective of this study was to evaluate the morphogenetic and structural characteristics of Aruana guineagrass pastures (Panicum maximum cv. Aruana) subjected to rotational stocking by sheep. The treatments corresponded to grazing when swards reached 95 or 98% of interception of incident light (LI) until post-grazing heights of 10 and 15cm and were
Zanini, Guilherme Doneda, Santos, Gabriela Trevisan, Sbrissia, André Fischer   +2 more
openaire   +4 more sources

Effect of perennial ryegrass (Lolium perenne L.) cultivars on the milk yield of grazing dairy cows

Animal, 2013
The objective of this experiment was to investigate the effect of four perennial ryegrass cultivars: Bealey, Astonenergy, Spelga and AberMagic on the milk yield and milk composition of grazing dairy cows. Two 4 × 4 latin square experiments were completed,
C.M. Wims, M. McEvoy, L. Delaby, T.M. Boland, M. O'Donovan   +4 more
doaj   +1 more source

Selective grazing by sheep as affected by the structure and composition of a Lolium perenne and Trifolium repens sward

, 1978
Perennial ryegrass/white clover swards were manipulated to give a range of clover contents and structures. The influence of sward composition and structure on diet selection was examined using oesoph-ageally fistulated sheep grazing four plots with ...
Mack, S. D.
core   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source