Results 231 to 240 of about 180,772 (296)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Light-switchable swarming of biohybrid microrobots. [PDF]

Sci Adv
de la Asunción-Nadal V, Nisula C, Cuntín-Abal C, Kobrin R, Mendis G, Latella J, Chen C, Jurado-Sánchez B, Zhang L, Escarpa A, Boisen A, Wang J.   +11 more
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Toward Interpretable Voice-Based Parkinson's Disease Screening via Joint Transfer Function-Feature-Classifier-Ensemble Selection. [PDF]

Bioengineering (Basel)
Yuan X, Zhang X, Xu H, Ye Q, Yuan C, Li H.   +5 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Bridging the Great Discordance: Ontological Intelligence as the New Paradigm in Spine Surgery. [PDF]

Neurospine
Kim JS.
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Self-reconfiguring modular robotic boats. [PDF]

Nat Commun
Wang W, Hagemann N, Gonzalez-Garcia A, Ratti C, Rus D.   +4 more
europepmc   +1 more source

Adaptive Digital Marketing: A Systematic Review of Bio-Inspired Reinforcement Learning, Multi-Agent Systems, and Agentic AI for Intelligent Optimisation. [PDF]

Biomimetics (Basel)
Adhikari TN, Sayers W, Zhang S.
europepmc   +1 more source

Adjusted Rand Index-Guided DPSO for Clustering and Data Routing in Wireless Sensor Networks. [PDF]

Sensors (Basel)
Mohi Dine SM, Zhu Z, Finnerty P, Ohta C.
europepmc   +1 more source