Results 31 to 40 of about 19,125 (136)

Downregulation of Organ‐Derived Activin A Attenuates Muscle Atrophy and Intramuscular Fat Infiltration in Cancer Cachexia Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Cancer cachexia is a multifactorial wasting syndrome marked by profound skeletal muscle loss. Tumours can release high levels of Activin A (ActA), which activates the ubiquitin‐proteasome pathway (UPP) and drives muscle wasting.
Cui Wang, Lin Gao, Rui Xue, Jia Su, Honghui Li, Wei Yang, Yan Tang, Zhihang Su, Shasha Min, Changyong Tang, Yuqi Zhu, Bo Mu, John R. Speakman, Xina Xie, Zesong Li   +14 more
wiley   +1 more source

Climate Change Impacts on Hydrology in the Upper James Watershed, Virginia

JAWRA Journal of the American Water Resources Association, Volume 62, Issue 2, April 2026.
ABSTRACT Hydrological modeling of the Upper James Watershed (UJW), Virginia, is critical for predicting water availability, flood management, agriculture, ecosystem protection, and hydropower production under increasing climate change. The Hydrologic Engineering Center–Hydrologic Modeling System (HEC‐HMS) is applied to evaluate climate change impacts ...
Imiya Mudiyanselage Chathuranika, Dalya Ismael   +1 more
wiley   +1 more source

Development of a SWAT+ Model to Improve Conservation Practice Efficacy for Protecting Stream Health in Karst Pasturelands

JAWRA Journal of the American Water Resources Association, Volume 62, Issue 2, April 2026.
ABSTRACT Placing appropriate conservation practices in critical source areas of pollutants can benefit stream health in karst environments susceptible to agricultural pollution. Watershed models, such as the Soil and Water Assessment Tool+ (SWAT+), can optimize both practice selection and placement across the landscape, but to our knowledge no studies ...
Joshua B. Mouser, Serena Ciparis, Michael J. White, Paul L. Angermeier, Jonathan A. Czuba   +4 more
wiley   +1 more source

Deciphering the Presence of Active Interscapular Brown Adipose Tissue in Humans

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Brown adipose tissue (BAT) is increasingly recognized as a metabolically active tissue in humans, although its physiological relevance remains incompletely understood. In rodents, BAT is well characterized, with interscapular BAT (iBAT) representing the main thermogenic depot.
Joaquin Sanchez‐Gomez, Samuel Ruiz‐Campos, Anabel Chica‐Perez, Andrés Baena‐Raya, Francisco M. Acosta, Christian Wolfrum, Patrick C. N. Rensen, Tania Romacho, Borja Martinez‐Tellez   +8 more
wiley   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, Volume 13, Issue 14, 9 March 2026.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

Atypical Presentation of Pediatric Spinal Tuberculosis as Chronic Abdominal Pain: A Case Report

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Spinal tuberculosis, also known as Pott's disease, in children is a rare manifestation of extrapulmonary tuberculosis. The nonspecific clinical features, such as chronic abdominal pain, of extrapulmonary TB or spinal TB in children tend to delay diagnosis.
Bilal Aslam, Faiza Farooq, Shafiq Ur Rahman, Fazeela Bibi, Umama Alam, Okasha Tahir, Adil Nawaz, Jibran Ikram   +7 more
wiley   +1 more source

Fahr's Syndrome in a Young Adult Male: A Case of Seizure and Cognitive Decline Secondary to Hypoparathyroidism

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Fahr's syndrome is a rare neurological condition characterized by bilateral intracranial calcifications secondary to metabolic or endocrine abnormalities, most commonly hypoparathyroidism. This condition is distinct from Fahr's disease (primary familial brain calcification), which is genetically inherited.
Sarah Nisar, Hamza Mushtaq, Muhammad Haris Khan, Fatima Sajjad, Abdullah Afridi, Zaryab Bacha, Bibi Hafza, Kamil Ahmad Kamil   +7 more
wiley   +1 more source

A Rare Case of Conjunctival and Scleral Necrosis Following Anterior Sub‐Tenon Triamcinolone Acetonide Injection in a Pediatric Patient

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT The sub‐Tenon route for injecting triamcinolone acetonide is one of the widely practiced surgical techniques for postoperative inflammation control, but complicated conjunctival and scleral necrosis are rare occurrences. A 3‐year‐old boy underwent bilateral cataract surgery and an anterior sub‐tendon injection of triamcinolone (AST) (20 mg ...
Muhammad Mateen Amir, Minahal Mateen, Bilal Aslam, Shafiq Ur Rahman, Fazeela Bibi, Khalil El Abdi, Said Hamid Sadat   +6 more
wiley   +1 more source