Results 271 to 280 of about 389,091 (415)

AMINO ACIDS IN HUMAN SWEAT

open access: bronze, 1951
Shinji Itoh, Teruo Nakayama
openalex   +2 more sources

Inhibition and Rescue of Hyperglycemia‐Induced Cellular Senescence by Mitochondrial Transfer from Enucleated Mesenchymal Stem Cell‐Derived Microvesicles for Chronic Wound Healing

open access: yesAdvanced Science, EarlyView.
This study develops enucleated MSC‐derived microvesicles (Mito@euMVs) to deliver functional mitochondria for optimizing wound repair. By efficiently encapsulating mitochondria, Mito@euMVs rejuvenate hyperglycemia‐induced senescent fibroblasts and HUVECs. Using PVA microneedle patches, the therapeutic efficacy of Mito@euMVs is validated in diabetic rats
Zixuan Dong   +3 more
wiley   +1 more source

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

open access: yesAdvanced Science, EarlyView.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su   +12 more
wiley   +1 more source

ε‐Poly‐L‐lysine‐graft‐oligo(3‐hexylthiophene) Copolymers as Antibacterial and Biodegradable Polymer Electronics

open access: yesAdvanced Science, EarlyView.
ε‐Poly‐L‐lysine‐graft‐oligo(3‐hexylthiophene) (EPL‐g‐O3HT) copolymers are engineered as biodegradable and antibacterial materials for transient electronics. EPL‐g‐O3HT exhibits tunable conductivity, controlled enzymatic degradability, good biocompatibility, and potent antibacterial activity. They are demonstrated in electromyography sensors and organic
Xin Sun   +9 more
wiley   +1 more source

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