Results 91 to 100 of about 610,219 (332)

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis [PDF]

, 2011
Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been ...
MacDonald, Alison, Harker, Mark, MacLaren, William, Alison MacDonald, Holmes, Susan L., Susan L. Holmes, Alistair D. Corbett, Mark Harker, Bovell, Douglas, Corbett, Alistair, Barbara A. Meyer, William M. MacLaren, Meyer, Barbara A., Douglas L. Bovell   +13 more
core   +1 more source

Sweat gland carcinomas in children [PDF]

Cancer, 1984
The clinicopathologic features of sweat gland carcinomas in three girls and one boy, aged 7 months to 10 years, are presented. The histologic and ultrastructural features suggested malignant clear cell acrospiromas. Rapid extensive metastases developed in two and early local recurrence in one. No obvious effect of chemotherapy was noted in disseminated
C W, Chow, P E, Campbell, A F, Burry
openaire   +2 more sources

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Non-invasive techniques for predicting soft tissue during pressure induced ishaemia. [PDF]

, 1997
PhDSoft tissue breakdown occurs in association with biochemical changes that can be attributed to a reduction in blood and lymph flow to a localised tissue area in response to applied pressure.
Knight, Sarah Louise
core  

Sweat gland LRCs are localized in the acinar gland region of SGs. [PDF]

, 2013
(A,B) H2BGFP is expressed in the epidermis and sweat glands before doxycycline treatment. (C,D) Sweat gland LRCs are found in the acinar gland region after 4 weeks of chase with doxycycline.
Eve Kandyba (460406), Yvonne Leung (460405), Seth Ruffins (356510), Krzysztof Kobielak (460407), Yi-Bu Chen (66776)   +4 more
core   +1 more source

Wilson protein expression, copper excretion and sweat production in sweat glands of Wilson disease patients and controls

BMC Gastroenterology, 2008
Background In Wilson disease, copper is not sufficiently excreted into bile due to the absence or malfunction of the Wilson protein copper ATPase in the excretory pathway of hepatocytes. Copper is found in sweat. It is unknown if the Wilson protein plays
Weiss Karl, Merle Uta, Schellenberg Mavi, Schaefer Mark, Stremmel Wolfgang   +4 more
doaj   +1 more source

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

Clinicopathologic Characteristics of 12 Patients With Vulvar Sweat Gland Carcinoma [PDF]

, 2010
Objectives:The aim of this article was to evaluate the clinical and pathologic characteristics, therapy, and prognostic factors of vulvar sweat gland carcinoma.Materials:Clinical and pathologic data for 12 patients with vulvar sweat gland carcinoma ...
Jin Lin Hou, Ne Nan Lv, Ying Huang, Hong Tu Zhang, Ling Ying Wu, Gau Zhi Yu   +5 more
core   +1 more source

Digital Papillary Adenocarcinoma Is HPV-42-Associated and BRAFV600E Negative: Perspectives for Diagnostic Practice

Dermatopathology
Digital papillary adenocarcinoma (DPAC) is a rare, low-grade sweat gland carcinoma primarily found on the hands, fingers, or toes and predominantly affecting males. Distinguishing DPAC from benign sweat gland tumors can be challenging.
Tassilo Dege, Arno Rütten, Matthias Goebeler, Hermann Kneitz   +3 more
doaj   +1 more source