Results 171 to 180 of about 605,445 (345)

LLM‐based prior elicitation for Bayesian graphical modeling

open access: yesBritish Journal of Mathematical and Statistical Psychology, EarlyView.
ABSTRACT In the Bayesian graphical modeling framework, priors on network structure encode theoretical assumptions and uncertainty about the topology of psychological constructs under study. For instance, the Bernoulli prior specifies the probability of each pairwise interaction, the Beta–Bernoulli prior governs expected network density, and the ...
Nikola Sekulovski   +2 more
wiley   +1 more source

Differential modularity of the mammalian Engrailed 1 enhancer network directs sweat gland development. [PDF]

open access: yesPLoS Genet, 2023
Aldea D   +7 more
europepmc   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz   +8 more
wiley   +1 more source

Primary Sweat Gland Adenocarcinoma of the Skin With ATL2::PRKD3 Fusion: A Potential Cutaneous Analog of Cribriform Adenocarcinoma of the Salivary Glands? [PDF]

open access: yesGenes Chromosomes Cancer
Brunet A   +8 more
europepmc   +1 more source

In situ forming injectable MSC-loaded GelMA hydrogels combined with PD for vascularized sweat gland regeneration. [PDF]

open access: yesMil Med Res, 2023
Jirigala E   +13 more
europepmc   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof   +8 more
wiley   +1 more source

3D-bioprinted microenvironments for sweat gland regeneration. [PDF]

open access: yesBurns Trauma, 2022
Song W   +6 more
europepmc   +1 more source

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