Results 161 to 170 of about 34,170 (296)

CDK4/6 inhibitor in combination with aromatase inhibitor effective in metastatic hidradenocarcinoma

open access: yes
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Valerie Glatzel   +6 more
wiley   +1 more source

Comprehensive management of vulvovaginal cancers

open access: yesCA: A Cancer Journal for Clinicians, EarlyView.
Abstract Vulvar and vaginal cancers represent rare malignancies, with an incidence of 2.7 per 100,000 women for vulvar cancer, predominantly affecting women older than 60 years, although rising rates are observed in younger demographics. Approximately 90% of vulvar cancers are squamous cell carcinoma and frequently are associated with human ...
Angélica Nogueira‐Rodrigues   +5 more
wiley   +1 more source

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

open access: yesMedicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni   +5 more
wiley   +1 more source

Double the Double: Revisiting BCL11B's Multimerization

open access: yesProteins: Structure, Function, and Bioinformatics, Volume 93, Issue 7, Page 1205-1211, July 2025.
ABSTRACT The transcription factor B Cell Lymphoma/Leukemia 11B (BCL11B) exerts a bi‐directional function in cancer, with its role as an emerging therapeutic target in cancer treatment being particularly intriguing. BCL11B knockouts in cultured T cells revealed the acquisition of properties characteristic of natural killer cells, hinting at its ...
Anne Susemihl   +5 more
wiley   +1 more source

Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives

open access: yesAmerican Journal of Hematology, Volume 100, Issue S4, Page 30-50, June 2025.
ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley   +1 more source

Functional Evaluation of Cooking‐Mimicking Extracts From Chinese Olive (Canarium album L.) Leaves, Fruits, and Pits Using Cell‐Based and In Silico Analysis

open access: yesFood Science &Nutrition, Volume 13, Issue 6, June 2025.
Bioactive components from Chinese olive extracts demonstrate anti‐inflammatory properties and inhibit human colorectal cancer cell proliferation by suppressing phosphofructokinase enzyme activity. ABSTRACT Chinese olive (CO; Canarium album L.) fruits are rich in phytochemicals with known physiological benefits.
Chun‐Wai Chan   +4 more
wiley   +1 more source

Antioxidant Natural Plant Constituents for Diabetic Wound Repair

open access: yesMedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
Antioxidant natural plant constituents promote diabetic wound repair by ameliorating oxidative stress, inhibiting inflammatory responses, and promoting tissue regeneration. ABSTRACT Diabetes mellitus is a prevalent metabolic disorder characterized by a prolonged hyperglycemic state, which can result in complications affecting multiple organ systems ...
Lele Meng   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy