Results 141 to 149 of about 91,551 (149)
Advanced Synthesis &Catalysis, EarlyView.We show how engineered ancestral amide bond synthetases (ABSs) together with cofactor recycling using a single polyphosphate kinase paves the way for chemoenzymatic synthesis of pharmacophores. The figure illustrates how ancestral ABS has a more flexible C‐terminal domain, which is associated with enhanced catalytic performance and expanded amine scope.
Elisabeth Söderberg +5 more
wiley +1 more source
Electrochemical Deoxygenation Electrolyzers Using an Organic Catalyst
Advanced Sustainable Systems, EarlyView.Conductive polymers offer a promising metal‐free route for the oxygen reduction reaction (ORR) in deoxygenation electrolyzers. The n‐type polymer demonstrates that BBL catalyzes ORR via a four‐electron pathway with high mass activity. A low‐voltage electrolyzer using BBL‐coated electrodes and catechol as a compensating redox additive efficiently ...
Armand Molaei +6 more
wiley +1 more source
Advanced Sustainable Systems, EarlyView.The shift to biodegradable materials in healthcare promises reduced plastic pollution, but their production, adoption, and long‐term impacts remain complex. Integrating lifecycle insights with global policy coordination is essential for meaningful environmental gains. Abstract The COVID‐19 pandemic sharply increased medical waste, intensifying concerns
By Haoxuan Yu +2 more
wiley +1 more source
Advanced Sustainable Systems, EarlyView.This work presents a novel, scalable method for manufacturing PFAS‐free cellulose‐based membranes for energy storage devices. By coating kraft paper with cellulose nanofibrils and optimizing barrier and ionic conductivity properties, membranes are achieved that prevent redox molecule crossover while maintaining performance.
Ioannis Petsagkourakis +5 more
wiley +1 more source
ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke
Advanced Science, EarlyView.Anesthesia‐induced preconditioning protects against perioperative stroke. By manipulating ATF5 in excitatory neurons, it is shown that anesthesia‐driven ATF5 upregulation activates the mitochondrial unfolded protein response (UPRmt) and elevates GDF15 expression.
Xianshu Ju +11 more
wiley +1 more source
Advanced Science, EarlyView.In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan +20 more
wiley +1 more source
Advanced Science, EarlyView.A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni +6 more
wiley +1 more source
Advanced Science, EarlyView.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva +28 more
wiley +1 more source