Results 141 to 150 of about 1,114,045 (263)
Advanced Science, EarlyView.High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao +10 more
wiley +1 more source
Weight trajectories throughout adulthood and prostate cancer incidence, aggressiveness, and death in 258 494 men. [PDF]
J Natl Cancer Instda Silva M +21 more
europepmc +1 more source
Advanced Science, EarlyView.This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong +6 more
wiley +1 more source
SPRINTR: Swedish PRecision medicine Initiative for Novel Treatments and Research-towards efficient recruitment to clinical trials for prostate cancer. [PDF]
Acta OncolWelén K +2 more
europepmc +1 more source
Advanced Science, EarlyView.This study addresses the rapid renal clearance of anti‐HER2 nanobodies by developing specialized liposomal carriers. It details the formulation of dual modified liposomes, demonstrating how PEGylation preserves structural integrity and cell‐penetrating peptides enhance cellular interaction.
Giulia Pander +14 more
wiley +1 more source
Treatment and progression of patients in Sweden with metastatic castration-sensitive prostate cancer. [PDF]
Acta OncolStyrke J +6 more
europepmc +1 more source
Breaking up the boreal – the impact of forest fragmentation on wood fungi and lichens
Fragmentation and habitat loss are major drivers of biodiversity loss in forest ecosystems. In boreal Sweden, rotation forestry has significantly altered landscape structure by transforming structurally rich old-growth and continuity forests into ...
Atrena, Anita
core
V2CTx MXene as a Sacrificial Promoter for NiFe Catalyst for Anion Exchange Membrane Electrolyzers
Advanced Science, EarlyView.These findings demonstrate that V2CTx functions beyond passive conductive support as an active electronic participant whose structural legacy sustains durable performance even after vanadium leaching in Anion Exchange Membrane (AEM) Electrolysers. ABSTRACT Nickel‐iron layered double hydroxides (NiFe‐LDH) show excellent activity, their poor conductivity
Bastian Schmiedecke +12 more
wiley +1 more source
Supportive Practices for Sustainable Hybrid Work
Today, approximately 80% of knowledge workers prefer a hybrid work model, combining onsite and remote work. During and in the wake of the pandemic, there were indications that employees experienced improved well-being, work-life balance (WLB), and ...
Tjernberg, Michaela
core
Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC
Advanced Science, EarlyView.Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang +13 more
wiley +1 more source