Results 211 to 220 of about 110,251 (296)

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, Volume 13, Issue 28, 18 May 2026.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

Reconstructing cerebral lymphatic clearance: an emerging target in the Alzheimer's disease therapeutic pipeline

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract Neurotoxic protein accumulation is widely recognized as a key feature of Alzheimer's disease (AD), and increasing evidence indicates that impaired brain clearance associated with dysfunction of the meningeal lymphatic and glymphatic may contribute to this process.
Jiheng Zhang, Jiren Zhang, Jian Ding, Xian Zhang, Yuhua Wang, Wei Wei, Yan Chai, Shu Zhang, Xin Chen   +8 more
wiley   +1 more source

Closing the Gaps: Integrating Biological, Ecological and Taxonomic Data to Support the Identification and Conservation of the Atlantic Pygmy Devil Ray (Mobula hypostoma)

Aquatic Conservation: Marine and Freshwater Ecosystems, Volume 36, Issue 5, May 2026.
ABSTRACT The Atlantic pygmy devil ray (Mobula hypostoma) is an endangered mobulid species whose conservation is hindered by taxonomic confusion and significant gaps in ecological and life history knowledge. Here, we present an integrative study that clarifies the species' taxonomic status, updates its distribution and synthesizes new and existing data ...
Atlantine Boggio‐Pasqua, Kim Bassos‐Hull, Guy M. W. Stevens, Jorge Manuel Morales‐Saldaña, Sylvain Adnet, Morgan A. Ferguson, Nicole A. Pelletier, Breanna C. DeGroot, Krystan A. Wilkinson, Emily Humble, Luis Fernando Del Moral‐Flores, Cody R. Mott, Jeffrey R. Guertin, Matthew J. Ajemian, Jessica Valek, Alexander Q. Fogg, Betty Laglbauer, Aristide Takoukam Kamla, Jessica H. Pate, Karen Fuentes, Lisa Hoopes, Ludwig Coulier, Michael Price, James Kinsler, Richard Collister, Ana Ferreira, Jennifer T. Wyffels, María del Pilar Blanco‐Parra, Ramо́n Bonfil, Juan Carlos Pérez‐Jiménez, Godefroy De Bruyne, Philip D. Doherty, Kristian Metcalfe, Youri Ivann Mvomo Minko, Andrielli M. Medeiros, Giuseppe Notarbartolo di Sciara   +35 more
wiley   +1 more source

Mathematical Model of Swimmer\u27s Itch with Praziquantel Treatment [PDF]

, 2016
Buch, Kelly R
core   +1 more source

Spatial Heterogeneity Among Threatened Fish Assemblages With High Endemicity Underscores the Urgency for Conservation Efforts

Aquatic Conservation: Marine and Freshwater Ecosystems, Volume 36, Issue 5, May 2026.
ABSTRACT Freshwater fish biodiversity faces immense pressures, especially in tropical developing regions where it provides critical protein and income. Effective conservation strategies require knowledge of species at scales matching their distribution and life history.
G. Glenn Wilson, Wassie Anteneh, Martin de Graaf, Eshete Dejen, Shewit Gebremedhin, Abebe Getahun, Alexander S. Golubtsov, Minwyelet Mingist, Arjan P. Palstra, Fedor N. Shkil, Fasil Taddese, Gizachew Teshome, Dereje Tewabe, Leopold A. J. Nagelkerke   +13 more
wiley   +1 more source

Fruquintinib Plus TAS‐102 With or Without SBRT as Third‐ Or Later‐Line Therapy for Metastatic Colorectal Cancer: Preliminary Results From a Prospective Phase II Trial

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Both fruquintinib and TAS‐102 monotherapies are guideline‐recommended for third‐line treatment of metastatic colorectal cancer (mCRC). This study aimed to analyze the preliminary outcomes of fruquintinib combined with TAS‐102, with or without stereotactic body radiation therapy (SBRT), as a third‐ or later‐line therapy for mCRC.
Yi Wang, Jianfen Xu, Linchun Liang, Yunjie Chen, Leizheng Fei, Jing Hu, Jianjiong Li, Yi Lu, Feng Ren, Ke Chen, Yanping Shen, Qingsong Tao, Zhi Fang, Kaitai Liu, Hua Ye, Jing Zhang, Yunbao Xu, Haoxun Mao, Chen Zhang, Chuangzhou Rao   +19 more
wiley   +1 more source

Lesser-Known Cyanotoxins: A Comprehensive Review of Their Health and Environmental Impacts. [PDF]

Toxins (Basel)
Al Haffar M, Fajloun Z, Azar S, Sabatier JM, Abi Khattar Z.   +4 more
europepmc   +1 more source

Safe Sport in Mediterranean Contexts: Cultural Logics of Harm, Silence, and Authority

European Journal of Sport Science, Volume 26, Issue 5, May 2026.
ABSTRACT This study explores how cultural logics, as articulated by system‐level actors in the Northern Mediterranean region, may shape the acceptance, tolerance, and normalisation of interpersonal violence in sport, and constrain efforts to develop and implement safe sport initiatives. Using a cultural praxis heuristic, we conducted 60 semi‐structured
Stiliani “Ani” Chroni, Eivind Å. Skille, Per Øystein Hansen, Antonis Alexopoulos, Juan de Dios Benítez‐Sillero, Ruth Brazier, Juan Calmaestra, Anna Kavoura, Renzo Kerr‐Cumbo, Sergio Lara‐Bercial, Alexander Navarro, Miguel Nery, Chiara Nicolini, Helena Verhelle, Sara Vivirito, Mary Hassandra   +15 more
wiley   +1 more source

Chemical Control of Snail Vectors as an Integrated Part of a Strategy for the Elimination of Schistosomiasis-A Review of the State of Knowledge and Future Needs. [PDF]

Trop Med Infect Dis
Garba Djirmay A, Yadav RS, Guo J, Rollinson D, Madsen H.   +4 more
europepmc   +1 more source