Results 71 to 80 of about 110,251 (296)
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
Two New Lyngbyatoxin Derivatives from the Cyanobacterium, Moorea producens
Marine Drugs, 2014 The toxin-producing cyanobacterium, Moorea producens, is a known causative organism of food poisoning and seaweed dermatitis (also known as “swimmer’s itch”). Two new toxic compounds were isolated and structurally elucidated from an ethyl acetate extract
Weina Jiang +9 more
doaj +1 more source
, 2018 Figure S3. Combined Distributions of Anas spp. Across Alberta Wetlands. (PDF 3152 kb)
Gordy, Michelle +2 more
openaire +1 more source
Swimmer's itch in Landmannalaugar, Iceland [PDF]
, 2007 Hægt er að lesa greinina í heild sinni með því að smella á hlekkinn View/OpenSwimmer's itch (SI) or human cercarial dermatitis is caused by free-swimming larvae of bird parasites of the family Schistosomatidae (Trematoda) which have penetrated thorough ...
Karl Skírnisson, Libusa Kolarova
core
Advanced Science, EarlyView.We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong +8 more
wiley +1 more source
Advanced Science, EarlyView.Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li +13 more
wiley +1 more source
Falling pupil numbers and school closures: Setting a research agenda for a new era of precarity
British Educational Research Journal, EarlyView.Abstract This paper explores the significant phenomenon of decreasing pupil numbers in England due to lower birth rates and the impact of a school closure on a school community. It then discusses how the sociology of education might research this major issue.
Eleanor Fagan, Alice Bradbury
wiley +1 more source
New Techniques to Detect Swimmer’s Itch Parasites in Lakes [PDF]
, 2018 Swimmer’s itch is caused by parasites called avian schistosomes. The main parasite that causes swimmer’s itch is Trichobilharzia stagnicolae. The T. stagnicolae life cycle uses common merganser ducks (COME) and snails as hosts Main problem: There is no ...
DeJong, Randall, Scholten, Bradley
core +1 more source
Lessons from primary school students' perceptions of the factors that influence school connectedness
British Educational Research Journal, EarlyView.Abstract School connectedness is critical to improving students' health, development and wellbeing. Research into primary school students' perceptions of the factors that influence their sense of connectedness is essential for identifying practices that promote success.
Jordana F. Hoenig, Therese M. Cumming
wiley +1 more source
Biomaterial design strategies for enhancing mitochondrial transplantation therapy
BMEMat, EarlyView.Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang +12 more
wiley +1 more source