Results 1 to 10 of about 61,173 (140)

A robust protocol for the generation of human midbrain organoids

open access: yesSTAR Protocols, 2021
Summary: The lack of advanced in vitro models recapitulating the human brain complexity is still a major obstacle in brain development and neurological disease research.
Alise Zagare   +3 more
doaj   +1 more source

Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response

open access: yesCell Reports, 2023
Summary: Treatment options for patients with NRAS-mutant melanoma are limited and lack an efficient targeted drug combination that significantly increases overall and progression-free survival.
Tijana Randic   +11 more
doaj   +1 more source

A research for analysing characteristics of university baseball players using swing measurement unit

open access: yesNihon Kikai Gakkai ronbunshu, 2021
In the field of sports engineering, though policies for developing human resources in sports are promoted nationally, lack of managers and coaches who can give highly-qualified instruction to an individual player is an urgent problem.
Shigenori TANAKA   +3 more
doaj   +1 more source

Gene regulatory network inference from sparsely sampled noisy data

open access: yesNature Communications, 2020
Gene regulatory network inference is a topical problem in systems biology. Here, the authors presents BINGO, a powerful method for network inference from time series data.
Atte Aalto   +4 more
doaj   +1 more source

Modulation of the IL-6-Signaling Pathway in Liver Cells by miRNAs Targeting gp130, JAK1, and/or STAT3

open access: yesMolecular Therapy: Nucleic Acids, 2019
Interleukin-6 (IL-6)-type cytokines share the common receptor glycoprotein 130 (gp130), which activates a signaling cascade involving Janus kinases (JAKs) and signal transducer and activator of transcription (STAT) transcription factors.
Florence A. Servais   +7 more
doaj   +1 more source

Periodontal abscess in a wild Amazon tapir Tapirus terrestris

open access: yesACI Avances en Ciencias e Ingenierías, 2012
Based on osteological evidence, we report an example of extensive bone erosion in association with advanced dental wear and molar loss in a wild tapir from eastern Ecuador.
Kelly Swing
doaj   +1 more source

Observations on the distribution and density of the rare and poorly known flower urchin, Toxopneustes roseus, (Phylum Echinodermata, Class Echinoidea, Family Toxopneustidae) in Ecuador

open access: yesACI Avances en Ciencias e Ingenierías, 2012
A southern range extension is reported for Toxopneustes roseus, the flower urchin, along the central continental coast of Ecuador. Indications are provided for likelihood of encountering this species.
Kelly Swing
doaj   +1 more source

FastField: An open-source toolbox for efficient approximation of deep brain stimulation electric fields

open access: yesNeuroImage, 2020
Deep brain stimulation (DBS) is a surgical therapy to alleviate symptoms of certain brain disorders by electrically modulating neural tissues. Computational models predicting electric fields and volumes of tissue activated are key for efficient parameter
Mehri Baniasadi   +4 more
doaj   +1 more source

A Correlational Analysis of Shuttlecock Speed Kinematic Determinants in the Badminton Jump Smash

open access: yesApplied Sciences, 2020
The forehand jump smash is an essential attacking stroke within a badminton player’s repertoire. A key determinate of the stroke’s effectiveness is post-impact shuttlecock speed, and therefore awareness of critical technique factors that ...
Mark King   +3 more
doaj   +1 more source

Extreme ectoparasitic behavior of Hood mockingbirds (Mimus macdonaldi) on marine iguanas (Amblyrhynchus cristatus) on the island of Española, Galapagos

open access: yesACI Avances en Ciencias e Ingenierías, 2012
Hood Mockingbirds, endemic to the island of Española in the Galapagos Archipelago, have been observed to be more aggressive than has been typically reported.
Kelly Swing
doaj   +1 more source

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