Results 131 to 140 of about 4,657,044 (399)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
The story of ALICE: Building the dedicated heavy ion detector at LHC [PDF]
'The Large Hadron Collider: A marvel technology', EPFL-Press
Lausanne, Switzerland, 2009 (Editor: L. Evans), chapter 5.4, 2011 This article documents the main design choices and the close to 20 years of preparation, detector R&D, construction and installation of ALICE, the dedicated heavy ion experiment at the CERN LHC accelerator.
arxiv
Antimicrobial Resistance: the use of antimicrobials in the Livestock Sector [PDF]
The use of antimicrobials in livestock production provides a basis for improving animal health and productivity. This in turn contributes to food security, food safety, animal welfare, protection of livelihoods and animal resources.
Ferreira, J P +3 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Unfolding algorithms and tests using RooUnfold [PDF]
Proceedings of the PHYSTAT 2011 Workshop, CERN, Geneva,
Switzerland, January 2011, CERN-2011-006, pp 313-318, 2011 The RooUnfold package provides a common framework to evaluate and use different unfolding algorithms, side-by-side. It currently provides implementations or interfaces for the Iterative Bayes, Singular Value Decomposition, and TUnfold methods, as well as bin-by-bin and matrix inversion reference methods.
arxiv
The passing of two great Swiss chemists [PDF]
, 1922 Philippe A. Guye, T. Sandmeyer
openalex +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Superconducting nano-layer coating without insulator [PDF]
Proceedings of the 27th Linear Accelerator Conference, LINAC14,
Geneva, Switzerland (2014), p. 1026, THPP074, 2014 The superconducting nano-layer coating without insulator layer is studied. The magnetic-field distribution and the forces acting on a vortex are derived. Using the derived forces, the vortex-penetration field and the lower critical magnetic field can be discussed.
arxiv
Money demand and inflation in Switzerland: an application of the Pascal technique [PDF]
Switzerland ; Money ; Inflation (Finance) ; Monetary policy ...
Tobias F. Rotheli
core