Results 161 to 170 of about 25,234 (258)

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

open access: yesAdvanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

Progetto SWS Heating - D6.8 Energy performance analysis of SWS-heating system in Sweden - RE-74/24

open access: yes
The purpose of this Delivery is to report on the results of the tests of the SWS-STES system done in Stockholm as the final stage of the SWS-Heating project. Results already included in earlier reports will only be repeated briefly when necessary for the
Klearchos Chalikakis   +14 more
core  

Representation of Slef in SWS and REM dreams

open access: yes, 2005
The aim of this study was to compare the representation of self in REM and SWS dreams. Ninety volunteers slept two non-consecutive nights in the sleep laboratory under electropolygraphic control. They were awakened for one report per night.
ESPOSITO, MARIA JOSE'   +4 more
core  

Brain-wide properties of slow waves across vigilance states. [PDF]

open access: yesSleep Adv
Yang S, Poole O, Walker MC, Sheybani L.
europepmc   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung   +15 more
wiley   +1 more source

Distinct Cleavage Trajectories Mediated by DNA and RNA Substrate in Argonaute From Methanocaldococcus Fervens

open access: yesAdvanced Science, EarlyView.
This study characterizes MfAgo, an enzyme exhibiting highly efficient DNA‐guided DNA and RNA cleavage capability. Precise RNA cleavage strictly requires dimerization to stabilize the PIWI‐loop region, while its robust DNA cleavage functions in a dimerization‐independent manner.
Fuyong Huang   +9 more
wiley   +1 more source

Sjögren's disease patients with no hyposalivation and with short oral dryness complaints contain more T cells in salivary gland parenchyma. [PDF]

open access: yesRheumatology (Oxford)
Yang T   +7 more
europepmc   +1 more source

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

open access: yesAdvanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie   +14 more
wiley   +1 more source

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