Results 41 to 50 of about 234,672 (296)

Telomere‐to‐Telomere Genomes Reveal that Multiscale Evolution Shapes the Largest Metabolic Arsenal of Diaporthe Fungi

Advanced Science, EarlyView.
This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li, Chen Zhang, Zhichao Zhang, Jiaheng Cheng, Qiuyan Gao, Long Gao, Xiaolin Zhao, Wei Yan, Yuanchao Wang, Wenwu Ye   +9 more
wiley   +1 more source

Symbiosis

, 2020
This music score was submitted for the Kaleidoscope 2020 Call for Scores, an open access collaboration with the UCLA Music Library.
Genoveva F. Esteban, Tom M. Fenchel
  +5 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Graph neural network-based remaining useful life prediction of milling tools using multi-sensor data

Discover Applied Sciences
Forecasting the Remaining Useful Life (RUL) of cutting tools plays a key role in intelligent predictive maintenance and downtime reduction in today’s manufacturing.
Satish Kumar, Dhruvi Ramaiya, Sameer Sayyad, Arunkumar Bongale, Vivek Warke, Vaibhav Joshi   +5 more
doaj   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Acute Myeloid Leukemia subtype classification using single blood cell images

Discover Oncology
Acute Myeloid Leukemia (AML) is a heterogeneous cancer that affects the myeloid lineage of blood cells. It requires accurate subtype identification for effective treatment.
Rhea Chainani, Ramitha Vimala, Sakshi Sah, Saharsh Mehrotra, Nilkanth Deshpande   +4 more
doaj   +1 more source

Genome‐Wide Association Study Reveals Insect Genetics and Microbial Symbiont Effects on Susceptibility of Diaphorina citri to the Citrus Greening Pathogen, Candidatus Liberibacter Asiaticus

Advanced Science, EarlyView.
This study investigates the genetic and microbial factors influencing the susceptibility of Diaphorina citri to the citrus greening pathogen Candidatus Liberibacter asiaticus (CLas), employing a microbiome Genome Wide Association Study. The research identifies a key gene encoding an MFS‐type transporter contributing to CLas infectivity and abundance in
Kai Liu, Qingcui He, Zeyue Lin, Shixuan Huang, Zichun Zhong, Pingyang Zhu, Mengge Gao, Luyao Zhao, Han Jin, Guiting Wu, Gurr M. Geoff, Qunxin Han, Rui Pang   +12 more
wiley   +1 more source

Review: missed tuberculosis cases in India: a systematic analysis of diagnostic, treatment, and reporting gaps

BMC Health Services Research
Background India aims to eliminate tuberculosis (TB) by 2025. Despite ongoing efforts to transform TB care, numerous factors contribute to the persistence of missing cases in India.
Rechel Shrisunder, Manesh Muraleedharan, Sammita Jagdish Jadhav, Dwight Figueiredo   +3 more
doaj   +1 more source

Optimizing micro cold storage for detecting stale food and fruits

Science and Technology for Energy Transition
Cold storage are a critical element of the food supply and sustainability supply chain for preservation and maintaining the quality as well as the nutritional value of stored items. This work investigates into the adoption of Artificial Intelligence (AI)
Arun Sreelekha, Amit Wagle Shivali, Nambiar Prahas, Panalkar Pratham, Ekka Prince, Kumar Vaibhav, Dhiman Harsh, Roy Anindita   +7 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source