Results 41 to 50 of about 622,762 (333)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Toeplitz Operators whose Symbols Are Borel Measures

open access: yesJournal of Function Spaces, 2021
In this paper, we are concerned with Toeplitz operators whose symbols are complex Borel measures. When a complex Borel measure μ on the unit circle is given, we give a formal definition of a Toeplitz operator Tμ with symbol μ, as an unbounded linear ...
Jaehui Park
doaj   +1 more source

Dirty black holes: Entropy as a surface term [PDF]

open access: yes, 1993
It is by now clear that the naive rule for the entropy of a black hole, {entropy} = 1/4 {area of event horizon}, is violated in many interesting cases.
Visser, Matt
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Formal verification by symbolic evaluation of partially-ordered trajectories [PDF]

open access: yesFormal Methods in System Design, 1995
Institute for Software ...
Carl-Johan H. Seger, Bryant, Randal E.
openaire   +2 more sources

Projective Metrizability and Formal Integrability [PDF]

open access: yes, 2011
The projective metrizability problem can be formulated as follows: under what conditions the geodesics of a given spray coincide with the geodesics of some Finsler space, as oriented curves.
Bucataru, Ioan, Muzsnay, Zoltán
core   +4 more sources

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

open access: yesFEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu   +6 more
wiley   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

open access: yesFEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

‘LEGIS ACTIO SACRAMENTO IN REM’ AS A RITUAL

open access: yesZeszyty Prawnicze
A ritual can be characterised as a form of conduct based on traditional and established rules. The basic purpose of its use is to confirm the validity of a particular action.
Marek Novák
doaj   +1 more source

SYNTHESIS AS A PSYCHOLOGICAL METHOD: EVIDENCE OF USING THE SEMANTIC DIFFERENTIAL METHOD

open access: yesRussian Journal of Education and Psychology, 2019
The purpose of the research is a psychological comprehension оf the conceptual and formal aspects of methodology. This paper presents a theoretical analysis of the integral paradigm and synthesis as used in psychology. It dwells upon a formal methodology
Tatyana Ivanovna Ray
doaj   +1 more source

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