Results 221 to 230 of about 27,878 (280)

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

PRTS: Predicting Single-Cell Spatial Transcriptomic Maps from Histological Images. [PDF]

Research (Wash D C)
Wen J, Zou L, Liu J, Guo X, Liu C, Wang B, Deng T, Liu C, Tang R, Yang Y, Huang Y, Yang L, Wang H, Li Z, Lin S, Liu S, Zhang Y, Hao Z, Zhou H, Huang H, Ling F.   +20 more
europepmc   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Development and validation of the family sports ecosystem questionnaire. [PDF]

Sci Prog
Zhang G, Jin C.
europepmc   +1 more source

Active Force Dynamics in Red Blood Cells Under Non‐Invasive Optical Tweezers

Advanced Science, EarlyView.
A non‐invasive method combines low‐power optical tweezers with high‐speed microscopy to simultaneously monitor local membrane forces and displacements in single human red blood cells. This dual‐channel approach reveals a mechano‐dynamic signature that correlates the cell's metabolic state with its mechanical activity. This energetic framework serves as
Arnau Dorn, Clara Luque‐Rioja, Macarena Calero, Diego Herráez‐Aguilar, Francisco Monroy, Niccolò Caselli   +5 more
wiley   +1 more source

A literature survey of shapelet quality measures for time series classification. [PDF]

PeerJ Comput Sci
Li T, Guo X, Ji C.
europepmc   +1 more source

QCMaquis 4.0: Multipurpose Electronic, Vibrational, and Vibronic Structure and Dynamics Calculations with the Density Matrix Renormalization Group. [PDF]

J Phys Chem A
Szenes K, Glaser N, Erakovic M, Barandun V, Mörchen M, Feldmann R, Battaglia S, Baiardi A, Reiher M.   +8 more
europepmc   +1 more source

Forecasting the rheological state properties of self-compacting concrete mixes using the response surface methodology technique for sustainable structural concreting. [PDF]

PLoS One
Zumba E, Velasco N, Melendres Medina EM, Bunay J, Estrada Brito NA, Onyelowe KC, Ganasen N, Hanandeh S.   +7 more
europepmc   +1 more source

LazyNet: Interpretable ODE Modeling of Sparse CRISPR Single-Cell Screens Reveals New Biological Insights. [PDF]

Biology (Basel)
Yi Z, Ma N, Ao Y.
europepmc   +1 more source

Using symbolic machine learning to assess and model substance transport and decay in water distribution networks. [PDF]

Sci Rep
Laucelli DB, Enríquez L, Saldarriaga J, Giustolisi O.   +3 more
europepmc   +1 more source