Results 41 to 50 of about 27,878 (280)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Forecasting, 2022 As the availability of big data-sets becomes more widespread so the importance of motif (or repeated pattern) identification and analysis increases. To date, the majority of motif identification algorithms that permit flexibility of sub-sequence length ...
Eoin Cartwright +2 more
doaj +1 more source
One-Step or Two-Step Optimization and the Overfitting Phenomenon: A Case Study on Time Series Classification [PDF]
, 2014 For the last few decades, optimization has been developing at a fast rate. Bio-inspired optimization algorithms are metaheuristics inspired by nature.
Fuad, Muhammad Marwan Muhammad
core +1 more source
Finding the Minimum-Weight k-Path [PDF]
, 2013 Given a weighted $n$-vertex graph $G$ with integer edge-weights taken from a range $[-M,M]$, we show that the minimum-weight simple path visiting $k$ vertices can be found in time $\tilde{O}(2^k \poly(k) M n^\omega) = O^*(2^k M)$.
B. Monien +8 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Symbolic Models for Stochastic Switched Systems: A Discretization and a Discretization-Free Approach [PDF]
, 2014 Stochastic switched systems are a relevant class of stochastic hybrid systems with probabilistic evolution over a continuous domain and control-dependent discrete dynamics over a finite set of modes.
Abate, Alessandro +2 more
core +3 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Journal of Medical Internet Research, 2021 BackgroundItaly has experienced severe consequences (ie, hospitalizations and deaths) during the COVID-19 pandemic. Online decision support systems (DSS) and self-triage applications have been used in several settings to ...
Alberto Eugenio Tozzi +7 more
doaj +1 more source
Chaos for Liouville probability densities
, 1995 Using the method of symbolic dynamics, we show that a large class of classical chaotic maps exhibit exponential hypersensitivity to perturbation, i.e., a rapid increase with time of the information needed to describe the perturbed time evolution of the ...
A. J. Lichtenberg +33 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source