Results 151 to 160 of about 1,973 (264)

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

An Information-Theoretic Model of Abduction for Detecting Hallucinations in Explanations. [PDF]

Entropy (Basel)
Galitsky B.
europepmc   +1 more source

Giant Switchable Remanent Polarization and Photocurrent in Ferroelectric Thin Film Photomemristor for In Situ Training

Advanced Science, EarlyView.
The device exhibits excellent ferroelectric performance and significant photoelectric response. It can adapt to light stimuli of varying power and wavelengths while achieving a stable and tunable photovoltaic response state. Moreover, the device can utilize photoconductive states of different directions and magnitudes to achieve pattern classification ...
Zhen Zhao, Chengze Sun, Zhijin Duo, Yue Hou, Zhanfeng Wang, Jikang Xu, Ziye Li, Fu Wang, Pengfei Li, Ying Liu, Yongqing Jia, Kangbo Zhao, Jia Wu, Biao Yang, Weifeng Zhang, Weidong Sun, Jiacheng Wang, Jinxia Liu, Junfeng Yu, Xiang Ying, Jianxin Guo, Xiaobing Yan   +21 more
wiley   +1 more source

Hybrid intelligence systems for reliable automation: advancing knowledge work and autonomous operations with scalable AI architectures. [PDF]

Front Robot AI
Grosvenor A, Zemlyansky A, Wahab A, Bohachov K, Dogan A, Deighan D.   +5 more
europepmc   +1 more source

A Perspective on Interactive Theorem Provers in Physics

Advanced Science, EarlyView.
Into an interactive theorem provers (ITPs), one can write mathematical definitions, theorems and proofs, and the correctness of those results is automatically checked. This perspective goes over the best usage of ITPs within physics and motivates the open‐source community run project PhysLean, the aim of which is to be a library for digitalized physics
Joseph Tooby‐Smith
wiley   +1 more source

VAM-Based Equivalent Cauchy Model for Accordion Honeycomb Structures with Zero Poisson's Ratio. [PDF]

Materials (Basel)
Lin Y, Chen M, Cai Z, Liu Z, Zhong Y, Liu R.   +5 more
europepmc   +1 more source

Microscale Mapping of Fiber Strain and Damage in Composite Wrinkled Laminates Using Computed Tomography Assisted Wide‐Angle X‐Ray Scattering

Advanced Science, EarlyView.
This study combines full‐field tomography with diffraction mapping to quantify radial (ε002$\varepsilon _{002}$) and axial (ε100$\varepsilon _{100}$) lattice strain in wrinkled carbon‐fiber specimens for the first time. Radial microstrain gradients (−14.5 µεMPa$\varepsilon \mathrm{MPa}$−1) are found to signal damage‐prone zones ahead of failure, which ...
Hoang Minh Luong, James Trevarthen, Igor Dolbnya, Wadwan Singhapong, Nicholas Pilato, Richard Butler, Jiraphant Srisuriyachot, Alexander J. G. Lunt   +7 more
wiley   +1 more source

vEMRec: High‐Resolution Volume Electron Microscopy Reconstruction Based on Structure‐Preserving and High‐Fidelity 3D Alignment

Advanced Science, EarlyView.
vEMRec is a frequency‐adaptive computational framework for three‐dimensional alignment in volume electron microscopy. It integrates feature‐based rigid alignment with Gaussian filter‐guided elastic registration to correct rigid misalignments and nonlinear distortions while preserving structural fidelity.
Zhenbang Zhang, Hongjia Li, Zhongjun Yang, Zhiqiang Xu, Duanchen Sun, Xin Gao, Fa Zhang, Renmin Han   +7 more
wiley   +1 more source

Bifurcation analysis and soliton solutions of the generalized third-order nonlinear Schrödinger equation using two analytical approaches. [PDF]

Sci Rep
Parveen S, Abbas M, Nazir T, Anwar MN, Alharthi MR, Yousaf MZ, Birhanu A.   +6 more
europepmc   +1 more source

Microfluidic‐Driven Lipid Nanoparticles for Improved miRNA Delivery via Endo‐Lysosomal Trafficking Optimization

Advanced Science, EarlyView.
This study investigates the impact of various post‐processing methods (filtration, sonication, dialysis, and heating) on lipid nanoparticles produced using microfluidics. The nanoparticles are designed for efficient delivery of miRNA into cells. The work highlights how processing conditions influence nanoparticle stability and quality, providing ...
Alicja Kosik‐Kozioł, Michał Pruchniewski, Daniel Rybak, Piotr Jenczyk, Karolina Zakrzewska, Magdalena Bartolewska, Sławomir Błoński, Paweł Nakielski, Filippo Pierini   +8 more
wiley   +1 more source