Results 51 to 60 of about 163,062 (337)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
A Novel Simplification Method for 3D Geometric Point Cloud Based on the Importance of Point
IEEE Access, 2019 3D point cloud simplification is an important pretreatment in surface reconstruction for sparing computer resources and improving reconstruction speed. However, existing methods often sacrifice the simplification precision to improve the simplification ...
Chunyang Ji +3 more
doaj +1 more source
DANet: Temporal Action Localization with Double Attention
Applied Sciences, 2023 Temporal action localization (TAL) aims to predict action instance categories in videos and identify their start and end times. However, existing Transformer-based backbones focus only on global or local features, resulting in the loss of information. In
Jianing Sun +7 more
doaj +1 more source
Symbolic-Numeric Computation [PDF]
, 2007 The growing demand of speed, accuracy, and reliability in scientific and engineering computing has been accelerating the merging of symbolic and numeric computations, two types of computation coexisting in mathematics yet separated in traditional research of mathematical computation.
Wang, Dongming, Zhi, Lihong
openaire +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
IEEE Access, 2019 Although there have been many successful multiclassification models in the field of image recognition in recent years, adding new classes to the trained models remains a research focus.
Yaosong Cheng +3 more
doaj +1 more source
Neural-Symbolic Learning and Reasoning: Contributions and Challenges [PDF]
, 2015 The goal of neural-symbolic computation is to integrate robust connectionist learning and sound symbolic reasoning. With the recent advances in connectionist learning, in particular deep neural networks, forms of representation learning have emerged ...
Besold, T. R. +9 more
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Batch Mode Active Learning for Node Classification in Assortative and Disassortative Networks
IEEE Access, 2018 Active learning for networked data that focuses on predicting the labels of other nodes accurately by knowing the labels of a small subset of nodes is attracting more and more researchers because it is very useful especially in cases, where labeled data ...
Shuqiu Ping +5 more
doaj +1 more source
AgeGuess, a Methylomic Prediction Model for Human Ages
Frontiers in Bioengineering and Biotechnology, 2020 Aging was a biological process under regulations from both inherited genetic factors and various molecular modifications within cells during the lifespan.
Xiaoqian Gao +7 more
doaj +1 more source