Results 41 to 50 of about 685,496 (293)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Student perspectives on the relationship between a curve and its tangent in the transition from Euclidean Geometry to Analysis [PDF]

, 2008
The tangent line is a central concept in many mathematics and science courses. In this paper we describe a model of students’ thinking – concept images as well as ability in symbolic manipulation – about the tangent line of a curve as it has developed ...
Artigue M., Castela C., Constantinos Christou, Fischbein E., Harel G., Harel G., Irene Biza, Janvier C., Marcoulides G.A., Muthen B., Muthen L.K., Tall D.O., Tall D.O., Tall D.O., Theodossios Zachariades, Tsamir P., Vinner S., Vinner S., Vinner S., Winicki G.   +19 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

REVEALING THE CULTURE OF SYMBOLIC VIOLENCE IN LANGUAGE LEARNING PRACTICES: LEARNING FROM KI HADJAR DEWANTARA [PDF]

ELT Echo: The Journal of English Language Teaching in Foreign Language Context
This study investigates the phenomenon of symbolic violence within the framework of language learning. Pierre Boudieu's notion of symbolic violence exposes the exercise of linguistic authority and ideology in educational activities. The ideas, doctrines,
Mohammad Andi Hakim, Syihabuddin
doaj   +1 more source

'Working out’ identity: distance runners and the management of disrupted identity [PDF]

, 2007
This article contributes fresh perspectives to the empirical literature on the sociology of the body, and of leisure and identity, by analysing the impact of long-term injury on the identities of two amateur but serious middle/long-distance runners ...
Allen Collinson J., Allen Collinson J., Allen Collinson J., Arthurs J., Becker G., Bendelow G., Blumer H., Brewer B., Coffey A., Dant T., Day Sclater S., Denison J., Denzin N. K., Ellis C., Ellis C., Frank A., Goffman E., Goffman E., Goffman E., Greenhalgh S., Grosz E. A., Hammersley M., Jacquelyn Allen Collinson, Jenkins R., John Hockey, Johnston L. H., Kotarba J. A., Krizek R. L., Leedy M. G., Lofland J., McCall G. J., Mead G. H., Nixon H. L., Ogles B. M., Pearce L., Perinbanayagam R. S., Petrie G., Pike E. C. J., Prus R., Reed‐Danahay D. E., Safai P., Shilling C., Smith J., Smith J., Smith S. L., Snow D. A., Sparkes A. C., Sparkes A. C., Sparkes A. C., Sparkes A. C., Stanley L., Stone G. P., Stryker S., Tedlock B., Tomlinson A., Tsang T., Tulle E., Williams S. J., Yair G., Young K., Young K.   +60 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Descriptive statistics for symbolic interval-valued data

The Indian Journal of Agricultural Sciences, 2014
It is, by now, well recognized that real data are in intervals and not in points. Unfortunately, classical statistical theory is not capable of handling data in intervals. Here, methodology for drawing univariate and bivariate histograms and computation
H K RANGANATH, PRAJNESHU, HIMADRI GHOSH
doaj   +1 more source

MENGHALAU DOMESTIFIKASI DAN FEODALISME: DAYA SUBJEKTIVITAS NH. DINI DALAM NOVEL JALAN BANDUNGAN

Puitika, 2020
The journey of Nh. Dini in fighting symbolicism can be examined through the relationship between Nh. Dini as a writer and her work sentitled Jalan Bandungan.
Nadya Afdholy, Tengsoe Tjahjono
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source