Results 51 to 60 of about 685,496 (293)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

KAJIAN SIMBOLIK KRESNA WANDA RONDON PADA WAYANG KULIT PURWA GARAPAN SAIMONO AGUS SUBIANTORO

Brikolase, 2018
This study examines focus on the symbolic meaning of shadow puppet Kresna wanda Rondon produced by Saimono Agus Subiantoro and background creation. This research is descriptive qualitative research.
Yuni Prastika Sari, Nunuk Nur Shokiyah
doaj   +1 more source

Spatial modelling for mixed-state observations

, 2008
In several application fields like daily pluviometry data modelling, or motion analysis from image sequences, observations contain two components of different nature.
Hardouin, Cécile, Yao, Jian-Feng
core   +3 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

3rd Workshop in Symbolic Data Analysis: book of abstracts [PDF]

, 2012
This workshop is the third regular meeting of researchers interested in Symbolic Data Analysis. The main aim of the event is to favor the meeting of people and the exchange of ideas from different fields - Mathematics, Statistics, Computer Science ...
Arroyo Gallardo, Javier, ed., Brito, Paula, ed., Maté, Carlos, ed., Noirhomme-Fraiture, Monique, ed.   +3 more
core  

Everyday cosmopolitanism in representations of Europe among young Romanians in Britain [PDF]

, 2018
The paper presents an analysis of everyday cosmopolitanism in constructions of Europe among young Romanian nationals living in Britain. Adopting a social representations approach, cosmopolitanism is understood as a cultural symbolic resource that is part
Billig M, Billig M, Bozatzis N, Buchowski M, Burrell K, Calhoun C, Caroline Howarth, Eleni Andreouli, Fox JE, Goffman E, Harvey D, Howarth C, McDowell L, Meleady R, Moscovici S, Neumann IB, Noble G, Nowicka M, Rabikowska M, Recchi E, Robbins B, Ryan L, Said E, Savage M, Sklair L, Stenning A, Tileaga C, Todorova M, Wessendorf S, Wessendorf S, Wolff L   +30 more
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A DSL for Resource Checking Using Finite State Automaton-Driven Symbolic Execution

Open Computer Science, 2020
Static analysis is an essential way to find code smells and bugs. It checks the source code without execution and no test cases are required, therefore its cost is lower than testing.
Fülöp Endre, Pataki Norbert
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source