AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz +4 more
wiley +1 more source
Transcendental model selection: a computational account of symbolic cognition and general intelligence through morality and culture. [PDF]
Rahman S, Pashea A.
europepmc +1 more source
stMixer for Scalable Mosaic Integration and Label Transfer in Spatial Histology and Multi‐Omics
stMixer is an unsupervised framework for scalable integration and label transfer across spatial histology and multi‐slide multi‐omics data with incomplete modality overlap. It combines self‐looped cross‐attention, multimodal metric learning, and graph‐guided cluster voting to align heterogeneous sections, correct batch effects, and propagate ...
Qixing Yang +3 more
wiley +1 more source
Neuro-symbolic reasoning engine for tax optimisation. [PDF]
Veeramani K, Joseph N A, M P.
europepmc +1 more source
Automated Extraction of Multicomponent Alloy Data Using Large Language Models for Sustainable Design
A large language model (LLM) based pipeline is developed to automatically extract a comprehensive and accurate multicomponent alloy database from literature corpus. The extracted dataset is integrated with sustainability indicators to identify potential alloys that outperform existing industrial benchmark materials in terms of both performance and ...
Aravindan Kamatchi Sundaram +4 more
wiley +1 more source
The 'Mental Health Crisis' and the Nonbeing of the Mad. [PDF]
Domingue JL, Foth T.
europepmc +1 more source
Ambiguous loss in family caregivers of patients in a permanent vegetative state: A reflexive thematic analysis. [PDF]
Testoni I +4 more
europepmc +1 more source
"A girl playing soccer?": a qualitative study of capital conversion and gendered power structures among Korean female athletes. [PDF]
Ahn H, Choi NY.
europepmc +1 more source
Multimodal Worlds, Multilingual Selves: Fictional Linguistic Landscapes in Transnational Education. [PDF]
Solmaz O.
europepmc +1 more source
From Gender Threat to Farsightedness: How Women's Perceived Intergroup Threat Shapes Their Long-Term Orientation. [PDF]
Shi Y, Zhao Y, Ma X, Chen S.
europepmc +1 more source

